Name: JD-5037
Brand: TargetMol
SKU: T4453
Price: 297 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 297

现货

2 mg

¥ 437

现货

5 mg

¥ 713

现货

10 mg

¥ 1,160

现货

25 mg

¥ 2,150

现货

50 mg

¥ 3,660

现货

100 mg

¥ 5,330

现货

500 mg

¥ 10,900

现货

1 mL x 10 mM (in DMSO)

¥ 898

现货

产品介绍

生物活性

产品描述	JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
靶点活性	CB1 receptor:1.5 nM
体内活性	JD5037 (3 mg/kg/d, i.p.) induces equal reductions in body weight, attenuates the HFD-induced hyperglycemia as well as reduces the HFD-induced hepatic injury and steatosis in obese Magel2-null mice. JD5037 (3 mg/kg/day, p.o.) significantly reduces the size of tumors and abrogates the tumor in DEN-treated mice. JD5037 attenuates the AEA levels in HCC samples from mice.
动物实验	Mice: JD-5037 is formulated in vehicle (V; 1% Tween80, 4% DMSO, 95% Saline). Obese mice are treated chronically (28 d) with vehicle (V; 1% Tween80, 4% DMSO, 95% Saline), JD5037, or SLV319 at a dose of 3 mg/kg, i.p. Body weight and food intake are monitored daily. Mice are euthanized by cervical dislocation under anesthesia; the brain, hypothalamus, liver, and combined fat pads are removed, weighed, and snap-frozen, and trunk blood is collected for determining the endocrine and biochemical parameters
别名	JD 5037

化学信息

分子量	572.51
分子式	C₂₇H₂₇Cl₂N₅O₃S
CAS No.	1392116-14-1
Smiles	CC(C)[C@H](\N=C(\NS(=O)(=O)c1ccc(Cl)cc1)N1C[C@@H](C(=N1)c1ccc(Cl)cc1)c1ccccc1)C(N)=O
密度	1.40 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (87.33 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.49 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

体内实验配液计算器