规格

价格

库存

数量

1 mg

¥ 297

现货

2 mg

¥ 437

现货

5 mg

¥ 713

现货

10 mg

¥ 1,160

现货

25 mg

¥ 2,150

现货

50 mg

¥ 3,660

现货

100 mg

¥ 5,330

现货

500 mg

¥ 10,900

现货

1 mL x 10 mM (in DMSO)

¥ 898

现货

生物活性

产品描述	JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
靶点活性	CB1 receptor:1.5 nM
体内活性	JD5037 (3 mg/kg/d, i.p.) induces equal reductions in body weight, attenuates the HFD-induced hyperglycemia as well as reduces the HFD-induced hepatic injury and steatosis in obese Magel2-null mice. JD5037 (3 mg/kg/day, p.o.) significantly reduces the size of tumors and abrogates the tumor in DEN-treated mice. JD5037 attenuates the AEA levels in HCC samples from mice.
动物实验	Mice: JD-5037 is formulated in vehicle (V; 1% Tween80, 4% DMSO, 95% Saline). Obese mice are treated chronically (28 d) with vehicle (V; 1% Tween80, 4% DMSO, 95% Saline), JD5037, or SLV319 at a dose of 3 mg/kg, i.p. Body weight and food intake are monitored daily. Mice are euthanized by cervical dislocation under anesthesia; the brain, hypothalamus, liver, and combined fat pads are removed, weighed, and snap-frozen, and trunk blood is collected for determining the endocrine and biochemical parameters
别名	JD 5037

化学信息

分子量	572.51
分子式	C₂₇H₂₇Cl₂N₅O₃S
CAS No.	1392116-14-1
Smiles	CC(C)[C@H](\N=C(\NS(=O)(=O)c1ccc(Cl)cc1)N1C[C@@H](C(=N1)c1ccc(Cl)cc1)c1ccccc1)C(N)=O
密度	1.40 g/cm3 (Predicted)

储存&溶解度

存储

Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 240 mg/mL (419.21 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.49 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7467 mL	8.7335 mL	17.4669 mL	87.3347 mL
5 mM	0.3493 mL	1.7467 mL	3.4934 mL	17.4669 mL
10 mM	0.1747 mL	0.8733 mL	1.7467 mL	8.7335 mL
20 mM	0.0873 mL	0.4367 mL	0.8733 mL	4.3667 mL
50 mM	0.0349 mL	0.1747 mL	0.3493 mL	1.7467 mL
100 mM	0.0175 mL	0.0873 mL	0.1747 mL	0.8733 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

JD-5037

JD-5037

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

JD-5037

JD-5037

JD-5037 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词