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Actarit

Name: Actarit
Brand: TargetMol
SKU: T0310
Price: 132 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.74%

货号 T0310Cas号 18699-02-0

别名 阿克他利, 4-acetylaminophenylacetic acid

Actarit (4-acetylaminophenylacetic acid) 是一种口服具有活性的化合物，可用于抗风湿研究以及 II 型胶原诱导性关节炎的研究。

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Actarit

一键复制产品信息

很棒

纯度: 99.74%

货号 T0310 别名 阿克他利, 4-acetylaminophenylacetic acidCas号 18699-02-0

Actarit (4-acetylaminophenylacetic acid) 是一种口服具有活性的化合物，可用于抗风湿研究以及 II 型胶原诱导性关节炎的研究。

规格	价格	库存
25 mg	¥ 132	现货
50 mg	¥ 178	现货
100 mg	¥ 247	现货
500 mg	¥ 572	现货
1 g	¥ 837	现货
1 mL x 10 mM (in DMSO)	¥ 148	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.74%

颜色: 白色

性状: Solid

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Actarit AI Summary

Actarit exhibits a range of bioactivities with potential therapeutic applications. It functions as an inhibitor with varied potencies across several biological targets: - Inhibits the malarial parasite plastid with a potency of 4256.2 nM. - Inhibits HP1-beta Chromodomain interactions with methylated histone tails with a potency of 100000.0 nM. - Blocks Ebola Virus entry with half-maximal inhibitory concentrations (AC50) at 39.81 µM and 39810.7 nM. The compound shows limited bioavailability or high metabolic conversion in the human body, demonstrated by a low recovery rate (0.6%) in urine following a dose of [14C]mirabegron. In terms of liver function, Actarit inhibits human BSEP activity with an IC50 value exceeding 1000000.0 nM, indicating a requirement for high concentrations to inhibit taurocholate transport. Antiviral activity is also observed: - Against SARS-CoV-2, moderate inhibition is noted in Vero E6 cells, with an inhibition index of 0.9755 (relative to arbidol control). - Inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 and Vero-6 cells at 10 µM after 48 hours, with varying inhibition percentages. - Shows inhibition of SARS-CoV-2 3CL-Pro protease at 20µM with percentages of 22.96% and 40.8% through FRET response from a peptide substrate. - Demonstrates antiviral activity against SARS-CoV-2 USA-WA1/2020 strain based on HRCE cell assays, with a hit score of 0.2693. For antifungal and antibacterial activity: - Shows antifungal activity against Cryptococcus neoformans H99 with a 4.09% inhibition rate. - Exhibits minimal antibacterial activity against several strains, including E. coli (3.54%), K. pneumoniae (4.76%), and A. baumannii (5.01%), but negative inhibition against Candida albicans (-0.65%) and Pseudomonas aeruginosa (-13.14%). In enzyme inhibition: - Shows slight inhibitory activity on human HDAC6 with percentages of -55.17% using a commercial substrate and -5.64% with a custom substrate. - Exhibits binding affinity and agonist/antagonist activities for various human and rat receptors and enzymes, with consistent AC50 values > 30000.0 nM. Overall, Actarit presents a diverse profile of bioactivities, including significant antiviral, antifungal, antibacterial, and enzyme inhibitory properties, suggesting its potential utility in treating multiple diseases..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Actarit (4-acetylaminophenylacetic acid) is an anti-inflammatory drug.
别名	阿克他利, 4-acetylaminophenylacetic acid

化学信息

分子量	193.2
分子式	C₁₀H₁₁NO₃
CAS No.	18699-02-0
Smiles	CC(=O)NC1=CC=C(CC(O)=O)C=C1
密度	1.288 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (284.68 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.35 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1760 mL	25.8799 mL	51.7598 mL	258.7992 mL
5 mM	1.0352 mL	5.1760 mL	10.3520 mL	51.7598 mL
10 mM	0.5176 mL	2.5880 mL	5.1760 mL	25.8799 mL
20 mM	0.2588 mL	1.2940 mL	2.5880 mL	12.9400 mL
50 mM	0.1035 mL	0.5176 mL	1.0352 mL	5.1760 mL
100 mM	0.0518 mL	0.2588 mL	0.5176 mL	2.5880 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。