PSB-1491

Name: PSB-1491
Brand: TargetMol
SKU: T24680
Price: 343 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.68%

货号 T24680Cas号 1619884-67-1

PSB-1491 是一种选择性和竞争性的单胺氧化酶 B 抑制剂，IC50 为 0.386 nM，是 MAO-A 的 25000 倍以上。

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PSB-1491

一键复制产品信息

很棒

纯度: 99.68%

货号 T24680Cas号 1619884-67-1

PSB-1491 是一种选择性和竞争性的单胺氧化酶 B 抑制剂，IC50 为 0.386 nM，是 MAO-A 的 25000 倍以上。

规格	价格	库存
1 mg	¥ 343	现货
5 mg	¥ 768	现货
10 mg	¥ 1,130	现货
25 mg	¥ 1,890	现货
50 mg	¥ 2,780	现货
100 mg	¥ 4,670	现货
500 mg	¥ 17,700	现货

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产品介绍

PSB-1491 AI Summary

PSB-1491 displays potent inhibitory activity as a selective monoamine oxidase (MAO) inhibitor, particularly targeting MAO-B over MAO-A. It has an IC50 of 1.32 nM for rat recombinant MAO-B and 0.386 nM for human recombinant MAO-B, while exhibiting very weak inhibition of human recombinant MAO-A with an IC50 greater than 10000 nM. The compound also shows strong binding affinity with a Ki value of 0.22 nM for human MAO-B. It demonstrates effective inhibition of other enzymes like AChE and BuChE, enhancing its bioactivity profile in neurotransmitter metabolism modulation. Additionally, PSB-1491 has good kinetic solubility, a favorable distribution coefficient in n-octanol-phosphate buffer, and moderate to high permeability in PAMPA assays, suggesting promising bioavailability and drug-like properties. With a potency index against safinamide greater than 13.0 and a high selectivity ratio (IC50 of 25907 for MAO-B over MAO-A), this compound presents a significant therapeutic potential as an MAO enzyme inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	PSB-1491 is a selective and competitive monoamine oxidase B inhibitor with IC50 of 0.386 nM, >25000-fold selective versus MAO-A.
靶点活性	MAO-B:0.386 nM(human)

化学信息

分子量	320.17
分子式	C₁₅H₁₁Cl₂N₃O
CAS No.	1619884-67-1
Smiles	CN1C=2C(=CC(C(NC3=CC(Cl)=C(Cl)C=C3)=O)=CC2)C=N1
密度	1.43 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (156.17 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1233 mL	15.6167 mL	31.2334 mL	156.1670 mL
5 mM	0.6247 mL	3.1233 mL	6.2467 mL	31.2334 mL
10 mM	0.3123 mL	1.5617 mL	3.1233 mL	15.6167 mL
20 mM	0.1562 mL	0.7808 mL	1.5617 mL	7.8084 mL
50 mM	0.0625 mL	0.3123 mL	0.6247 mL	3.1233 mL
100 mM	0.0312 mL	0.1562 mL	0.3123 mL	1.5617 mL