Diphenylcyclopropenone

Name: Diphenylcyclopropenone
Brand: TargetMol
SKU: T21444
Rating: 4.5 (1 reviews)

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很棒

纯度: 99.25%

货号 T21444Cas号 886-38-4

别名 二苯基环丙烯酮, DPCP, Diphencyprone

Diphenylcyclopropenone (DPCP) 是局部免疫调节剂，可用于研究斑秃。

Diphenylcyclopropenone

一键复制产品信息

很棒

纯度: 99.25%

货号 T21444 别名 二苯基环丙烯酮, DPCP, DiphencyproneCas号 886-38-4

Diphenylcyclopropenone (DPCP) 是局部免疫调节剂，可用于研究斑秃。

规格	价格	库存	数量
200 mg	¥ 99	待询
1 mL x 10 mM (in DMSO)	¥ 163	现货

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纯度: 99.25%

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COA LCMS HNMR 产品操作手册

产品介绍

Diphenylcyclopropenone AI Summary

Diphenylcyclopropenone shows a wide range of bioactivities across multiple assays, indicating its potential as a multi-target bioactive molecule. It is potent in modulating splicing of Lamin A, miRNAs, and miR-21, and exhibits inhibitory activity against Tau fibril formation and ROR gamma transcriptional activity. The compound also modulates lipid storage, inhibits Schistosoma Mansoni Peroxiredoxins, induces DNA re-replication in various cell models, and inhibits tyrosyl-DNA phosphodiesterase 1. Additionally, Diphenylcyclopropenone displays antiviral activity against multiple pathogens including SARS-CoV-2, Lassa Virus, Marburg Virus, and Ebola Virus. Specifically, it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, with an IC50 value greater than 20000 nM, and shows SARS-CoV-2 3CL-Pro protease inhibition at 20 µM with an inhibition rate of 10.52%. Moreover, the compound exhibits antibacterial activities against Escherichia coli, Acinetobacter baumannii, and Staphylococcus aureus, although it shows negative inhibition against Klebsiella pneumoniae. Antifungal activities were also observed against Candida albicans and Cryptococcus neoformans. Furthermore, Diphenylcyclopropenone acts as an inhibitor of human HDAC6, with 68.42% inhibition using a commercial peptide substrate and 10.54% inhibition using a custom peptide substrate, underscoring its potential for epigenetic regulation. Overall, Diphenylcyclopropenone demonstrates diverse bioactivities, making it a promising candidate for further research and development across various therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Diphenylcyclopropenone (DPCP) is a topical drug used to treat alopecia areata, alopecia totalis, and refractory warts. Diphencyprone acts as a local stimulator that triggers an immune response against the action of autoreactive cells.
别名	二苯基环丙烯酮, DPCP, Diphencyprone

化学信息

分子量	206.24
分子式	C₁₅H₁₀O
CAS No.	886-38-4
Smiles	O=C1C(=C1C1=CC=CC=C1)C1=CC=CC=C1
密度	1.232 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 88 mg/mL (426.69 mM), Sonication is recommended.

H2O: Insoluble

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (16 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8487 mL	24.2436 mL	48.4872 mL	242.4360 mL
5 mM	0.9697 mL	4.8487 mL	9.6974 mL	48.4872 mL
10 mM	0.4849 mL	2.4244 mL	4.8487 mL	24.2436 mL
20 mM	0.2424 mL	1.2122 mL	2.4244 mL	12.1218 mL
50 mM	0.0970 mL	0.4849 mL	0.9697 mL	4.8487 mL
100 mM	0.0485 mL	0.2424 mL	0.4849 mL	2.4244 mL