Name: H-1152 dihydrochloride
Brand: TargetMol
SKU: T35328
Price: 539 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 539

In stock

2 mg

¥ 787

In stock

5 mg

¥ 1,490

In stock

10 mg

¥ 2,380

In stock

25 mg

¥ 3,980

In stock

50 mg

¥ 5,680

In stock

100 mg

¥ 7,680

In stock

200 mg

¥ 9,870

In stock

1 mL x 10 mM (in DMSO)

¥ 1,320

In stock

产品介绍

生物活性

产品描述	H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
靶点活性	PKA (cell-free assay):3.03 μM, Src:3.06 μM, AMPK:100 μM, p38α:100 μM, CaMK II (cell-free assay):0.180 μM, PKC:5.68 μM, MKK4:16.9 μM, GSK-3α:60.7 μM, EGFR:50 μM, Aurora A (cell-free assay):0.745 μM, PKG (cell-free assay):0.360 μM, ROCK2 (cell-free assay):0.0120 μM, Abl:7.77 μM, MLCK:28.3 μM
体外活性	H-1152 dihydrochloride shows less inhibitory activities against Src, MLCK, Abl, EGFR, MKK4, GSK3α, AMPK, and P38α, with IC50s of 3.06, 28.3, 7.77, 50.0, 16.9, 60.7, 100, and 100 μM, respectively[1]. H-1152 dihydrochloride slightly suppresses PKA, PKC and MLCK, with Kis of 0.63, 9.27, and 10.1 μM, respectively. In LPA-treated cells, H-1152 dihydrochloride (0.1-10 µM) inhibits MARCKS phosphorylation (IC50 = 2.5 µM)[2]. H-1152 dihydrochloride (0.5-10 μM) does not decrease neuronal survival or alter the ratios of different neuronal morphologies. H-1152 dihydrochloride (10 μM) arguments neurite length in both BMP4 and LIF cultures[3].
别名	H-1152 dihydrochloride, H-1152 2HCl

化学信息

分子量	392.34
分子式	C₁₆H₂₃Cl₂N₃O₂S
CAS No.	871543-07-6
Smiles	Cl.Cl.C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(C)c12
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 40 mg/mL (101.95 mM), Sonication is recommended.

H2O: 32.1 mg/mL (81.9 mM ), Sonication is recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5488 mL	12.7440 mL	25.4881 mL	127.4405 mL
5 mM	0.5098 mL	2.5488 mL	5.0976 mL	25.4881 mL
10 mM	0.2549 mL	1.2744 mL	2.5488 mL	12.7440 mL
20 mM	0.1274 mL	0.6372 mL	1.2744 mL	6.3720 mL
50 mM	0.0510 mL	0.2549 mL	0.5098 mL	2.5488 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0255 mL	0.1274 mL	0.2549 mL	1.2744 mL

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH₂O，那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300/ PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

H-1152 dihydrochloride

H-1152 dihydrochloride

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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