Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H-1152 dihydrochloride (H-1152 2HCl) 是 Rho 相关蛋白激酶 (ROCK) 的特异性抑制剂,IC50 为 12 nM,Ki 为 1.6 nM。 H-1152 dihydrochloride 抑制 PKA、PKC、PKG、Aurora A 和 CaMKII,IC50 值分别为 3.03 μM、5.68 μM、0.360 μM、0.745 μM 和 0.180 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 632 | 现货 | ||
2 mg | ¥ 929 | 现货 | ||
5 mg | ¥ 1,530 | 现货 | ||
10 mg | ¥ 2,460 | 现货 | ||
25 mg | ¥ 4,530 | 现货 | ||
50 mg | ¥ 6,480 | 现货 | ||
100 mg | ¥ 8,820 | 现货 | ||
500 mg | ¥ 17,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,320 | 现货 |
产品描述 | H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively. |
靶点活性 | ROCK2 (cell-free assay):0.0120 μM, PKG (cell-free assay):0.360 μM, Aurora A (cell-free assay):0.745 μM, CaMK II (cell-free assay):0.180 μM, PKA (cell-free assay):3.03 μM |
体外活性 | H-1152 dihydrochloride shows less inhibitory activities against Src, MLCK, Abl, EGFR, MKK4, GSK3α, AMPK, and P38α, with IC50s of 3.06, 28.3, 7.77, 50.0, 16.9, 60.7, 100, and 100 μM, respectively[1]. H-1152 dihydrochloride slightly suppresses PKA, PKC and MLCK, with Kis of 0.63, 9.27, and 10.1 μM, respectively. In LPA-treated cells, H-1152 dihydrochloride (0.1-10 µM) inhibits MARCKS phosphorylation (IC50 = 2.5 µM)[2]. H-1152 dihydrochloride (0.5-10 μM) does not decrease neuronal survival or alter the ratios of different neuronal morphologies. H-1152 dihydrochloride (10 μM) arguments neurite length in both BMP4 and LIF cultures[3]. |
别名 | H-1152 2HCl, H-1152 dihydrochloride |
分子量 | 392.34 |
分子式 | C16H23Cl2N3O2S |
CAS No. | 871543-07-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (114.7 mM ), Sonication is recommended.
H2O: 32.1 mg/mL (81.9 mM ), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 2.5488 mL | 12.744 mL | 25.4881 mL | 63.7202 mL |
5 mM | 0.5098 mL | 2.5488 mL | 5.0976 mL | 12.744 mL | |
10 mM | 0.2549 mL | 1.2744 mL | 2.5488 mL | 6.372 mL | |
20 mM | 0.1274 mL | 0.6372 mL | 1.2744 mL | 3.186 mL | |
50 mM | 0.051 mL | 0.2549 mL | 0.5098 mL | 1.2744 mL | |
DMSO | 100 mM | 0.0255 mL | 0.1274 mL | 0.2549 mL | 0.6372 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
H-1152 dihydrochloride 871543-07-6 Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells ROCK H-1152 2HCl H-1152 Dihydrochloride H 1152 H 1152 dihydrochloride H1152 Dihydrochloride H 1152 Dihydrochloride H1152 dihydrochloride H1152 H-1152 Inhibitor inhibitor inhibit