Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VB124 是一种具有口服活性的、有效且选择性的MCT4抑制剂。VB124 可特异性抑制 MDA-MB-231 细胞中乳酸的涌入和流出,IC50分别为 8.6 nM 和 19 nM。VB124 对 MCT4 的选择性高于 MCT1。VB124可用于心脏肥大、心力衰竭和代谢的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,220 | 现货 | ||
5 mg | ¥ 2,970 | 现货 | ||
10 mg | ¥ 4,960 | 现货 | ||
25 mg | ¥ 7,580 | 现货 | ||
50 mg | ¥ 9,870 | 现货 | ||
100 mg | ¥ 13,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,380 | 现货 |
产品描述 | VB124 is an orally active, potent, and selective inhibitor of MCT4. VB124 can specifically inhibit lactate efflux with IC 50 s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism [1]. |
体外活性 | VB124 (10 μM) inhibits the cell proliferation of MDA-MB-231 cells, and the cell proliferation rate is less than 50% [1]. VB124 is more selective to MCT4 than MCT1, exhibiting very little MCT1 inhibitory activity (lactate export IC 50 =24 μM) in MCT1-expressing BT20 cells [1]. |
体内活性 | VB124 (30 mg/kg; p.o.; daily for 28 days) reduces isoproterenol-induced cardiac hypertrophy in mice [1]. VB124 (30 mg/kg; twice per day for 180 days) has no effect on the body, heart, liver, or lung weight of mice, suggesting no overt toxicities [1]. Animal Model: 12 weeks old C57BL/6 mice [1] Dosage: 30 mg/kg Administration: Oral gavage; daily for 28 days (dissolved in 0.5% methylcellulose and 0.1% Tween-20) Result: Prevented cardiac hypertrophy in mice. |
分子量 | 426.89 |
分子式 | C23H23ClN2O4 |
CAS No. | 2230186-18-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90mg/mL (210.8mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3425 mL | 11.7126 mL | 23.4252 mL | 58.5631 mL |
5 mM | 0.4685 mL | 2.3425 mL | 4.685 mL | 11.7126 mL | |
10 mM | 0.2343 mL | 1.1713 mL | 2.3425 mL | 5.8563 mL | |
20 mM | 0.1171 mL | 0.5856 mL | 1.1713 mL | 2.9282 mL | |
50 mM | 0.0469 mL | 0.2343 mL | 0.4685 mL | 1.1713 mL | |
100 mM | 0.0234 mL | 0.1171 mL | 0.2343 mL | 0.5856 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
VB124 2230186-18-0 Membrane transporter/Ion channel Monocarboxylate transporter VB-124 VB 124 Inhibitor inhibitor inhibit