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Nocodazole (Oncodazole) 是一种微管聚合抑制剂,具有可逆性,也是一种 Bcr-Abl 的抑制剂。Nocodazole 具有抗肿瘤活性,可以阻滞细胞周期,诱导细胞凋亡。
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Nocodazole (Oncodazole) 是一种微管聚合抑制剂,具有可逆性,也是一种 Bcr-Abl 的抑制剂。Nocodazole 具有抗肿瘤活性,可以阻滞细胞周期,诱导细胞凋亡。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 256 | In stock | |
10 mg | ¥ 416 | In stock | |
25 mg | ¥ 856 | In stock | |
50 mg | ¥ 1,470 | In stock | |
100 mg | ¥ 2,510 | In stock | |
200 mg | ¥ 3,750 | In stock | |
500 mg | ¥ 5,920 | 5日内发货 | |
1 mL x 10 mM (in DMSO) | ¥ 256 | In stock |
Nocodazole 相关产品
产品描述 | Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis. |
靶点活性 | B-Raf (V600E):1.1 μM (Kd), Abl (T315I):0.64 μM, MET:1.7 μM (Kd), MEK2:1.6 μM (Kd), BRAF:1.8 μM (Kd), PI3Kγ:1.5 μM (Kd), MEK1:1.7 μM (Kd), Abl:0.21 μM, Abl (E255K):0.53 μM, c-Kit:1.6 μM (Kd) |
体外活性 | 方法:红细胞用 Nocodazole (15-60 µg/mL) 处理 48 h,使用 Annexin-V-FITC 检测磷脂酰丝氨酸。 |
体内活性 | 方法:为检测体内抗肿瘤活性,将 Nocodazole (12 mg/kg,每周三次) 和 dexamethasone (2 mg/kg,每周两次) 腹腔注射给携带骨髓瘤 H929 的免疫缺陷小鼠,持续十五天。 |
细胞实验 | Nocodazole is dissolved in a final concentration of 0.05% DMSO. Proteins are loaded at 50 μg/lane and separated by 12% (w:v) sodium dodecyl sulfate-polyacrylamide gel electrophoresis, blotted, and probed with antibodies for cyclin E, p53, p21/CIP1, p27/KIP1, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), cyclin A, cyclin D1, cyclin D3, cyclin B, CDK2, CDK4, and cytochrome C. Immunoreactive bands are visualized by incubating with the colorigenic substrates nitroblue tetrazolium and 5-bromo-4-chloro-3-indolyl-phosphate. The expression of GAPDH is used as the control for equal protein loading. |
别名 | 诺考达唑, R17934, Oncodazole |
分子量 | 301.32 |
分子式 | C14H11N3O3S |
CAS No. | 31430-18-9 |
Smiles | COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c1cccs1 |
密度 | 1.49 g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
溶解度信息 | DMSO: 12.5 mg/mL (41.48 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
DMSO
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以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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