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PRE-084 hydrochloride

Name: PRE-084 hydrochloride
Brand: TargetMol
SKU: T3198L
Price: 143 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.54%

货号 T3198LCas号 75136-54-8

PRE-084 hydrochloride 是 σ1 的选择性激动剂在sigma 受体检测中，IC50值为44 nM。

PRE-084 hydrochloride

一键复制产品信息

很棒

纯度: 99.54%

货号 T3198LCas号 75136-54-8

PRE-084 hydrochloride 是 σ1 的选择性激动剂在sigma 受体检测中，IC50值为44 nM。

规格	价格	库存
1 mg	¥ 143	现货
5 mg	¥ 328	现货
10 mg	¥ 529	现货
25 mg	¥ 1,070	现货
50 mg	¥ 2,110	现货
100 mg	¥ 3,150	现货
1 mL x 10 mM (in DMSO)	¥ 585	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.54%

颜色: 白色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

PRE-084 hydrochloride AI Summary

PRE-084 hydrochloride has been extensively tested for its bioactivities and has demonstrated a wide-ranging spectrum of effects. It shows potency in inhibiting the proliferation of various Plasmodium falciparum lines, with IC50 values ranging from 4466.8 nM to 14125.4 nM. Additionally, PRE-084 hydrochloride exhibits activity against endonuclease IV, the Menin-MLL interaction in leukemias, lipid storage modulation, histone lysine methyltransferase G9a, and delayed death inhibitors of the malarial parasite. It also affects HP1-beta chromodomain interactions with methylated histone tails, the human hERG channel, Marburg virus entry, Hepatitis C virus, and human tyrosyl-DNA phosphodiesterase 1 (TDP1), and induces synthetic lethality in 2HG-producing tumor cells. PRE-084 hydrochloride acts as an agonist at the sigma1 receptor in rat PC12 cells, enhancing NGF-induced neurite outgrowth by 27.5% and increasing neurite length by 181.3 um at 10 μM concentration over 5 days. This agonist activity persists in the presence of a sigma1 receptor antagonist BD-1063, albeit with reduced effectiveness, showing a decrease in neurite outgrowth by 16.0% and neurite length by 140.1 um. Similar trends are observed with another antagonist BD-1064, showing a decrease in neurite length by 23.0%. The compound exhibits high affinity for the sigma1 receptor with Ki values of 58.7 nM and 66.6 nM in the presence of DPH, but has significantly lower affinity (150.8 nM) in the DPH solvent. It shows minimal binding to kappa and delta opioid receptors, indicating selectivity towards sigma1 receptors under these assay conditions. Additionally, PRE-084 hydrochloride exhibits antiviral properties; it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, with inhibition rates of 17.53% and 1.21%, respectively, after 48 hours at 10 μM concentration, determined through high content imaging. Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease by 13.0% at a concentration of 20 µM as measured by a FRET-based assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).

化学信息

分子量	353.88
分子式	C₁₉H₂₈ClNO₃
CAS No.	75136-54-8
Smiles	Cl.O=C(OCCN1CCOCC1)C1(CCCCC1)c1ccccc1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 31 mg/mL (87.6 mM), Sonication is recommended.

H2O: 35.4 mg/mL (100.03 mM), Sonication and heating are recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.65 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8258 mL	14.1291 mL	28.2582 mL	141.2908 mL
5 mM	0.5652 mL	2.8258 mL	5.6516 mL	28.2582 mL
10 mM	0.2826 mL	1.4129 mL	2.8258 mL	14.1291 mL
20 mM	0.1413 mL	0.7065 mL	1.4129 mL	7.0645 mL
50 mM	0.0565 mL	0.2826 mL	0.5652 mL	2.8258 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0283 mL	0.1413 mL	0.2826 mL	1.4129 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

PRE-084 hydrochloride

PRE-084 hydrochloride

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

PRE-084 hydrochloride

PRE-084 hydrochloride