3-Bromopyruvic acid

Name: 3-Bromopyruvic acid
Brand: TargetMol
SKU: T5882
Price: 326 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.644%

货号 T5882Cas号 1113-59-3

别名 Hexokinase II Inhibitor II, 3-BP, Bromopyruvic acid, 3-溴丙酮酸

3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) 是己糖激酶 II 抑制剂，是针对肝癌细胞的一种抗肿瘤剂。

3-Bromopyruvic acid

一键复制产品信息

很棒

纯度: 99.644%

货号 T5882 别名 Hexokinase II Inhibitor II, 3-BP, Bromopyruvic acid, 3-溴丙酮酸Cas号 1113-59-3

3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) 是己糖激酶 II 抑制剂，是针对肝癌细胞的一种抗肿瘤剂。

规格	价格	库存
500 mg	¥ 326	现货
1 g	¥ 395	现货
5 g	¥ 578	现货
10 g	¥ 788	现货

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COA HNMR LCMS 产品操作手册

产品介绍

3-Bromopyruvic acid AI Summary

3-Bromopyruvic acid exhibits a range of inhibitory activities across several biological targets. It is a reversible inhibitor of Escherichia coli dihydrodipicolinate synthase, demonstrating inhibition with a Ki value of 160,000 nM. The compound also inhibits the Mycobacterium tuberculosis ICL1 enzyme with an IC50 value of 17,500 nM and shows a binding affinity with a melting temperature of 52.5 degrees Celsius. Additionally, 3-Bromopyruvic acid shows antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 and Caco-2 cells, with inhibition rates of -0.01% and 10.28% at 10 µM, respectively, and exhibits an IC50 value greater than 20,000 nM. It also inhibits the SARS-CoV-2 3CL-Pro protease, with an inhibition rate of 41.31% at 20 µM. Furthermore, the compound reduces human HDAC6 activity by 12.68% and 5.09% using different peptide substrates. It has notable activity against bacterial enzymes, including NDM-1 (IC50: 2570 nM, Ki: 3800 nM), VIM-2 (IC50: 18,700 nM), IMP-1 (IC50: 28,900 nM), ImiS, and L1 (both IC50 > 40,000 nM)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
靶点活性	Hexokinase II:2.4 mM (Ki)
别名	Hexokinase II Inhibitor II, 3-BP, Bromopyruvic acid, 3-溴丙酮酸

化学信息

分子量	166.96
分子式	C₃H₃BrO₃
CAS No.	1113-59-3
Smiles	OC(=O)C(=O)CBr
密度	2.011 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 122.5 mg/mL (733.71 mM)

H2O: 32 mg/mL (191.66 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.98 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9895 mL	29.9473 mL	59.8946 mL	299.4729 mL
5 mM	1.1979 mL	5.9895 mL	11.9789 mL	59.8946 mL
10 mM	0.5989 mL	2.9947 mL	5.9895 mL	29.9473 mL
20 mM	0.2995 mL	1.4974 mL	2.9947 mL	14.9736 mL
50 mM	0.1198 mL	0.5989 mL	1.1979 mL	5.9895 mL
100 mM	0.0599 mL	0.2995 mL	0.5989 mL	2.9947 mL