Gamabufotalin

Name: Gamabufotalin
Brand: TargetMol
SKU: T4A2456
Price: 2380 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.51%

货号 T4A2456Cas号 465-11-2

别名 日本蟾蜍毒苷元, Gamabufagin

Gamabufotalin (Gamabufagin) 是一种蟾蜍甾烯，存在于蟾酥中。它稳定性高，毒性低，被广泛用于癌症的研究。

Gamabufotalin

一键复制产品信息

很棒

纯度: 99.51%

货号 T4A2456 别名 日本蟾蜍毒苷元, GamabufaginCas号 465-11-2

Gamabufotalin (Gamabufagin) 是一种蟾蜍甾烯，存在于蟾酥中。它稳定性高，毒性低，被广泛用于癌症的研究。

规格	价格	库存
1 mg	¥ 322	现货
5 mg	¥ 813	现货
10 mg	¥ 1,390	现货
25 mg	¥ 2,380	现货
50 mg	待询	现货
1 mL x 10 mM (in DMSO)	¥ 893	现货

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产品介绍

Gamabufotalin AI Summary

Gamabufotalin exhibits significant inhibitory and cytotoxic activities against various human cell lines. For the primary liver carcinoma (PLC) cell line PLC/PRF/5, it has an IC50 of 0.00023 µg/mL, and against the colchicine-resistant PLC/PRF/5 parent line, the IC50 is 0.0008 µg/mL. It shows cytotoxicity against human KB cells (IC50 of 0.75 µg/mL) and human HL60 cells (IC50 of 0.014 µg/mL) after 72 hours by MTT assay but is not significantly cytotoxic against mouse MH60 cells (IC50 > 25.0 µg/mL). Additionally, Gamabufotalin demonstrates potent antiproliferative activity against human Hep3B and Huh-7 cells with IC50 values of 27.0 nM and 23.0 nM, respectively. It significantly induces apoptosis in these cell lines, with notable activity at concentrations of 15 nM, 20 nM, and 25 nM after 48 hours. These pro-apoptotic effects persist even in the presence of inhibitors like Z-VAD-FMK and chloroquine..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	1. Gamabufotalin (Gamabufagin) , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect.
别名	日本蟾蜍毒苷元, Gamabufagin

化学信息

分子量	402.52
分子式	C₂₄H₃₄O₅
CAS No.	465-11-2
Smiles	C[C@]12C[C@@H](O)[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@]34C)[C@@]1(O)CC[C@@H]2c1ccc(=O)oc1
密度	1.289 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (62.11 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.97 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4843 mL	12.4217 mL	24.8435 mL	124.2174 mL
5 mM	0.4969 mL	2.4843 mL	4.9687 mL	24.8435 mL
10 mM	0.2484 mL	1.2422 mL	2.4843 mL	12.4217 mL
20 mM	0.1242 mL	0.6211 mL	1.2422 mL	6.2109 mL
50 mM	0.0497 mL	0.2484 mL	0.4969 mL	2.4843 mL