购物车

您的购物车当前为空

HC-056456

Name: HC-056456
Brand: TargetMol
SKU: T4604
Price: 248 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: HC 056456, 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide

货号 T4604Cas号 7733-96-2 一键复制产品信息纯度: 99.65%

很棒

HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide) 是一种有效但不完全选择性的 CatSper 通道阻断剂。它能够减慢 [Na+]i 上升(IC50:3 µM)。

HC-056456

一键复制产品信息

很棒

纯度: 99.65%

货号 T4604Cas号 7733-96-2

别名 HC 056456, 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide

HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide) 是一种有效但不完全选择性的 CatSper 通道阻断剂。它能够减慢 [Na+]i 上升(IC50:3 µM)。

规格	价格	库存
1 mg	¥ 248	现货
5 mg	¥ 723	现货
10 mg	¥ 1,130	现货
25 mg	¥ 2,310	现货
50 mg	¥ 3,980	现货
100 mg	¥ 5,530	现货
1 mL x 10 mM (in DMSO)	¥ 743	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.65%

颜色: 白色至黄色

资源下载: COA LCMS HNMR产品操作手册

产品介绍

HC-056456 AI Summary

HC-056456 demonstrates a wide array of bioactivities across various biological systems and targets. It notably inhibits Schistosoma mansoni TGR with significant efficacy, displaying an IC50 value of 40.0 nM and an inhibition percentage of -101.0%. Additionally, it exerts potent antiviral activity against SARS-CoV-2, inhibiting the 3CL-Pro protease with an inhibition percentage of 91.02% at 20µM and an IC50 value greater than 20.0 µM for the proteolytic cleavage of a dual-labeled substrate. HC-056456 also presents cytotoxicity against VERO-6 and HepG2 cell lines, with IC50 values of 10 µM and 1800 nM, respectively. Beyond its antiviral and anti-parasitic effects, HC-056456 modulates a wide range of biological activities, including Lamin A splicing, inhibition of Human Jumonji Domain Containing 2E, induction of genomic imprint erasure, and inhibition of tau fibril formation. It targets various pathways and functions, such as the ERK signaling pathway, TGF-b, and WRN helicase, with noted IC50 and EC50 values, indicating its potency across different bioactivities. Furthermore, the compound inhibits the CatSper1 channel in human sperm, thereby reducing sperm hyperactivity and motility. These multifaceted bioactivities suggest that HC-056456 holds substantial potential for therapeutic applications across a spectrum of diseases and conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide) is a CatSper channel modulator.
靶点活性	CatSper channel:3 µM
别名	HC 056456, 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide

化学信息

分子量	306.32
分子式	C₁₂H₆N₂O₄S₂
CAS No.	7733-96-2
Smiles	[O-][n+]1onc(C(=O)c2cccs2)c1C(=O)c1cccs1
密度	1.67 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 150 mg/mL (489.68 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2646 mL	16.3228 mL	32.6456 mL	163.2280 mL
5 mM	0.6529 mL	3.2646 mL	6.5291 mL	32.6456 mL
10 mM	0.3265 mL	1.6323 mL	3.2646 mL	16.3228 mL
20 mM	0.1632 mL	0.8161 mL	1.6323 mL	8.1614 mL
50 mM	0.0653 mL	0.3265 mL	0.6529 mL	3.2646 mL
100 mM	0.0326 mL	0.1632 mL	0.3265 mL	1.6323 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。