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Phenprocoumon

Name: Phenprocoumon
Brand: TargetMol
SKU: T7636
Price: 117 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.98%

货号 T7636Cas号 435-97-2

别名 乙苄香豆, 苯丙羟基香豆素

Phenprocoumon 是一种长效口服抗凝剂和维生素 K 的拮抗剂，是香豆素衍生物。

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Phenprocoumon

一键复制产品信息

很棒

纯度: 97.98%

货号 T7636 别名 乙苄香豆, 苯丙羟基香豆素Cas号 435-97-2

Phenprocoumon 是一种长效口服抗凝剂和维生素 K 的拮抗剂，是香豆素衍生物。

规格	价格	库存
2 mg	¥ 117	现货
5 mg	¥ 178	现货
10 mg	¥ 286	现货
25 mg	¥ 496	现货
50 mg	¥ 798	现货
100 mg	¥ 1,180	现货
200 mg	¥ 1,730	现货
1 mL x 10 mM (in DMSO)	¥ 197	现货

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COA LCMS HPLC HNMR 产品操作手册

产品介绍

Phenprocoumon AI Summary

Phenprocoumon demonstrates a moderate partition coefficient (LogP = 3.62), indicating its ability to balance between aqueous and lipid environments. It has a low dissociation constant (pKa = 5.0), suggesting predominant existence in a specific ionization state under certain conditions. The compound exhibits moderate binding affinity to human serum albumin (Log B/F = 2.128) and weak binding to guinea pig atrial homogenate (Log B/F = 0.396). Phenprocoumon is a potential inhibitor of HIV protease with reported Ki values ranging from 0.8 nM to 1000.0 nM, suggesting binding variations under different conditions. It has shown antiviral activity in HIV-1 infected PBMCs with an ED50 of 300.0 μM and inhibited HIV protease in MT-4 cells with an IC50 of 1000.0 nM. The compound exhibits moderate liver toxicity, with hepatotoxicity reported at 6 times the upper limit for ALT or AST serum levels or 1.7 times for alkaline phosphatase. This moderate toxicity was observed in 37% of clinical trials, with acute liver toxicity reported in 18% of cases. Phenprocoumon demonstrates anticoagulant activity by increasing prothrombin time in rats and exhibits drug uptake in the liver. It also inhibits VKORC1 with a Ki value of 200.0 nM. Additionally, it shows modest antiviral activity against SARS-CoV-2 in various cell lines, including HRCE cells and VERO-6 cells, with an IC50 above 20,000 nM. Furthermore, the compound inhibits human HDAC6 activity, showing 16.18% inhibition in an enzymatic assay. It also exhibits significant binding affinity to HIV protease, with a notable Ki value of 0.8 nM, highlighting its potential as an inhibitor for antiviral therapy. Overall, Phenprocoumon displays multiple bioactivities, including enzyme inhibition, antiviral activity, and potential hepatotoxicity, making it a candidate for further investigation in diverse therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Phenprocoumon is an antagonist of vitamin K(IC50:1 μM).
靶点活性	Vitamin K:1 μM
别名	乙苄香豆, 苯丙羟基香豆素

化学信息

分子量	280.32
分子式	C₁₈H₁₆O₃
CAS No.	435-97-2
Smiles	CCC(c1ccccc1)c1c(O)c2ccccc2oc1=O
密度	1.261g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (445.92 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.27 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5674 mL	17.8368 mL	35.6735 mL	178.3676 mL
5 mM	0.7135 mL	3.5674 mL	7.1347 mL	35.6735 mL
10 mM	0.3567 mL	1.7837 mL	3.5674 mL	17.8368 mL
20 mM	0.1784 mL	0.8918 mL	1.7837 mL	8.9184 mL
50 mM	0.0713 mL	0.3567 mL	0.7135 mL	3.5674 mL
100 mM	0.0357 mL	0.1784 mL	0.3567 mL	1.7837 mL