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PD 169316

Name: PD 169316
Brand: TargetMol
SKU: T2432
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.65%

货号 T2432Cas号 152121-53-4

PD 169316 是一种细胞渗透性 p38 MAP 激酶抑制剂，IC50值为 89 nM。它可选择性地抑制磷酸化 p38 的激酶活性。

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PD 169316

一键复制产品信息

很棒

纯度: 98.65%

货号 T2432Cas号 152121-53-4

PD 169316 是一种细胞渗透性 p38 MAP 激酶抑制剂，IC50值为 89 nM。它可选择性地抑制磷酸化 p38 的激酶活性。

规格	价格	库存
1 mg	¥ 198	现货
5 mg	¥ 463	现货
10 mg	¥ 712	现货
25 mg	¥ 1,280	现货
50 mg	¥ 1,930	现货
100 mg	¥ 2,880	现货

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纯度: 98.65%

颜色: 黄色

性状: Solid

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

PD 169316 AI Summary

PD 169316 exhibits a diverse range of bioactivities. It notably inhibits interleukin-1 (IL-1) synthesis in human monocytes with an IC50 of 50.0 nM and shows inhibitory activity against p38 MAP kinase with an IC50 of 89.0 nM. The compound also affects the thermal stability of several protein kinases involved in various signaling pathways, including AMPKA2, CAMK proteins, CDKs, GSK3B, JAK1~B, MEK2, ERKs, PAKs, and PLKs, indicating potential modulation of their activities. Additionally, PD 169316 demonstrates moderate antiplasmodial activity against strains of Plasmodium falciparum, with IC50 values ranging from 3162.28 nM to 6309.57 nM. It shows strong inhibitory activity in modulating Lamin A splicing with a potency of 4.5 nM and acts as an agonist for the NFkB signaling pathway at 12589.3 nM. Moreover, it inhibits APE1 with an IC50 of 15848.9 nM and TDP1 with potencies ranging from 15848.9 nM to 56234.1 nM. PD 169316 also inhibits 5-lipoxygenase with an IC50 of 8000.0 nM and demonstrates 16.87% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM, along with a minor antiviral effect against SARS-CoV-2 cytotoxicity in VERO-6 cells at 10 µM concentration. It reduces melanin synthesis by inhibiting tyrosinase in mouse B16F10 cells, showing an IC50 of 89.0 nM. Lastly, the compound exhibits cytotoxicity against human HepG2 cells with an IC50 of 50000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.
靶点活性	p38 MAPk:89 nM.

化学信息

分子量	360.34
分子式	C₂₀H₁₃FN₄O₂
CAS No.	152121-53-4
Smiles	FC1=CC=C(C2=C(N=C(N2)C3=CC=C(N(=O)=O)C=C3)C=4C=CN=CC4)C=C1
密度	1.345 g/cm3

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 7.9 mg/mL (21.92 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7752 mL	13.8758 mL	27.7516 mL	138.7578 mL
5 mM	0.5550 mL	2.7752 mL	5.5503 mL	27.7516 mL
10 mM	0.2775 mL	1.3876 mL	2.7752 mL	13.8758 mL
20 mM	0.1388 mL	0.6938 mL	1.3876 mL	6.9379 mL

计算器

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稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。