规格

价格

库存

数量

1 mg

¥ 2,630

现货

5 mg

¥ 6,300

现货

10 mg

¥ 8,630

现货

25 mg

¥ 12,800

现货

50 mg

¥ 17,200

现货

生物活性

产品描述	VK-1727, a selective small molecule inhibitor of EBNA1, reduces the DNA binding activity of EBNA1 while simultaneously restricting the proliferation and metabolic activity of EBV-positive cells, it does so without influencing the viability of EBV-negative cells, thereby demonstrating specificity. VK-1727 is primarily employed in researchs that focus on multiple sclerosis, in which it serves as a tool compound to interrogate EBNA1-mediated mechanisms in disease-related processes.
体外活性	方法：VK-1727 (25 μM, 72小时) 处理EBV+ 细胞，通过流式细胞术检测细胞周期。结果：VK-1727显著减少了EBV+细胞（HC1-2、SMS1-3和AMS1-4）中G2期细胞的总数，而在EBV-B细胞中则未观察到类似效应。[1]
别名	VK1727

化学信息

分子量	451.51
分子式	C₂₉H₂₅NO₄
Smiles	COC(C1=CC=CC(C#CC(C=C2)=CC=C2OC3CCOCC3)=C1C4=CC=C(C=CN5)C5=C4)=O

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 80 mg/mL (177.18 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.31 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2148 mL	11.0740 mL	22.1479 mL	110.7395 mL
5 mM	0.4430 mL	2.2148 mL	4.4296 mL	22.1479 mL
10 mM	0.2215 mL	1.1074 mL	2.2148 mL	11.0740 mL
20 mM	0.1107 mL	0.5537 mL	1.1074 mL	5.5370 mL
50 mM	0.0443 mL	0.2215 mL	0.4430 mL	2.2148 mL
100 mM	0.0221 mL	0.1107 mL	0.2215 mL	1.1074 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

VK-1727

VK-1727

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

VK-1727

VK-1727

VK-1727 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换