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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Glucosamine

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纯度: 99.8%

货号 T0429Cas号 3416-24-8

别名 葡糖胺, 氨基葡萄糖, D-Glucosamine, Chitosamine

Glucosamine (Chitosamine) 是天然产物。Glucosamine 用作膳食补充剂。Glucosamine 外用时对骨关节炎软骨和软骨细胞具有药理作用。Glucosamine 调节糖代谢。Glucosamine 降低胰岛匀浆液中葡糖激酶的活性。

Glucosamine
其他形式的 “Glucosamine”:
D-Glucosamine 6-phosphate
Glucosamine hydrochloride (Standard)
Glucosamine 6-sulfate
Glucosamine sulfate
Glucosamine hydrochloride

Glucosamine

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Rating icon 很棒

纯度: 99.8%

货号 T0429 别名 葡糖胺, 氨基葡萄糖, D-Glucosamine, ChitosamineCas号 3416-24-8

Glucosamine (Chitosamine) 是天然产物。Glucosamine 用作膳食补充剂。Glucosamine 外用时对骨关节炎软骨和软骨细胞具有药理作用。Glucosamine 调节糖代谢。Glucosamine 降低胰岛匀浆液中葡糖激酶的活性。

规格价格库存数量
50 mg
¥ 150
现货
1 mL x 10 mM (in DMSO)
¥ 170
现货
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产品介绍

生物活性
产品描述
Glucosamine (Chitosamine) is a natural product. Glucosamine is used as a dietary supplement. Glucosamine has pharmacological effects on cartilage and chondrocytes in osteoarthritis when used externally. Glucosamine regulates sugar metabolism. Glucosamine reduces the activity of glucoskinase in pancreatic islet homogenate.
靶点活性
superoxide:47.67 mM (IC20), DPPH:21.32 mM, hydroxyl:14.04 mM
体外活性

方法：YD-8人舌癌细胞用Glucosamine（10 mM）处理 4 小时，使用western blot检测相关蛋白的磷酸化水平。
结果：Glucosamine抑制 HIF-1α，降低 p70S6K 和 S6 翻译相关蛋白的磷酸化。[1]
方法：肾细胞用Glucosamine（5 mM）处理12、24、36小时，使用western blot检测靶点蛋白表达水平。
结果：Glucosamine显著降低梗阻肾脏和 TGF-β1 处理的肾细胞中 α-平滑肌肌动蛋白、胶原蛋白 I 和纤连蛋白的肾脏表达。[2]

体内活性

方法：为研究Glucosamine对骨损伤的影响，将Glucosamine（20 mg/kg/day）口服给药小鼠，持续30天。
结果：Glucosamine显著减少软骨损伤和骨赘形成。[3]

别名葡糖胺, 氨基葡萄糖, D-Glucosamine, Chitosamine
化学信息
分子量179.17
分子式C6H13NO5
CAS No.3416-24-8
SmilesN[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO
密度1.563 g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
H2O: 200.9 mM, Sonication is recommended.
DMSO: 58 mg/mL (323.71 mM), Sonication is recommended.
溶液配制表
H2O/DMSO
1mg5mg10mg50mg
1 mM5.5813 mL27.9065 mL55.8129 mL279.0646 mL
5 mM1.1163 mL5.5813 mL11.1626 mL55.8129 mL
10 mM0.5581 mL2.7906 mL5.5813 mL27.9065 mL
20 mM0.2791 mL1.3953 mL2.7906 mL13.9532 mL
50 mM0.1116 mL0.5581 mL1.1163 mL5.5813 mL
100 mM0.0558 mL0.2791 mL0.5581 mL2.7906 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

TargetMol AI Summary
Glucosamine shows a binding affinity for the 16S ribosomal RNA A-site of Escherichia coli, with a Kd value of approximately 1000000.0 nM. It has demonstrated various biological activities in different assays. In rat studies, it affected plasma GPT and GOT levels, and altered concentrations of several ceramides in plasma and liver tissues, indicating potential impacts on liver function and lipid metabolism. It also increased plasma and hepatic vitamin C levels in Wistar rats when administered intraperitoneally at 1 g/kg, with effects observed over 24 hours. The compound exhibited anti-inflammatory activity in carrageenan-induced paw edema and antiarthritic activity in a Mycobacterium tuberculosis-induced rat arthritic model, with notable reduction at 250 mg/kg. In human OCT1 studies, it inhibited the uptake of 4-(4-(dimethylamino)styryl)-N-methylpyridinium at 100 uM. In bovine articular cartilage explants, it reduced IL1-induced glycosaminoglycan release and showed cytotoxicity against bovine chondrocytes at various concentrations. Furthermore, Glucosamine exhibited antifungal activity by inhibiting mycelial growth of Poria placenta FPRL 280 and Trametes versicolor Quel. CTB 863-A at specified concentrations. It induced the activity of Heparan-alpha-glucosaminide N-acetyltransferase N273K mutant in skin fibroblasts at 14 mM concentration. However, in anti-viral activity assays against SARS-CoV-2, it showed a low hit score of 0.1709. The compound also inhibited the binding affinity to V5-His tagged FIBCD1 ecto-domain at 50 mM. Despite these varied effects, Glucosamine showed no significant bioactivity in multiple receptor and enzyme assays, with AC50 values exceeding 30000.0 nM..
Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl

关键词

TNF-αReactiveOxygenSpeciesReactive Oxygen SpeciesNF-κBNFκBNF-kBNFkBMMP-9InhibitorinhibitIFγHypoxia-inducible factorsHIFsHIFProlylHydroxylaseHIF-PHHIF/HIFProlylHydroxylaseHIF/HIF Prolyl-HydroxylaseHIF/HIF ProlylHydroxylaseHIF Prolyl-HydroxylaseHIF ProlylHydroxylaseHIFGlucosamineEndogenousMetaboliteEndogenous MetaboliteChitosanaseAutophagy
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