Aklomide

Name: Aklomide
Brand: TargetMol
SKU: T0390
Price: 163 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.65%

货号 T0390Cas号 3011-89-0

别名 阿克洛胺, Alkomide, 2-Chloro-4-nitrobenzamide

Aklomide (2-Chloro-4-nitrobenzamide) 用于家禽治疗寄生虫。

Aklomide

一键复制产品信息

很棒

纯度: 99.65%

货号 T0390 别名 阿克洛胺, Alkomide, 2-Chloro-4-nitrobenzamideCas号 3011-89-0

Aklomide (2-Chloro-4-nitrobenzamide) 用于家禽治疗寄生虫。

规格	价格	库存
100 mg	¥ 163	现货
500 mg	¥ 475	现货
1 g	¥ 693	现货
1 mL x 10 mM (in DMSO)	¥ 179	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.65%

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COA HNMR LCMS 产品操作手册

产品介绍

Aklomide AI Summary

Aklomide exhibits a broad spectrum of bioactivity and inhibitory effects in various assays. It acts as an inhibitor of the MLL CXXC domain-DNA interaction with a potency of 50118.7 nM. In the context of malarial research, it functions as a delayed death inhibitor of the malarial parasite plastid, demonstrating potencies of 10691.0 nM and 19011.5 nM after 96-hour and 48-hour incubation assays, respectively. In virology, Aklomide blocks the entry of the Ebola virus with AC50 values ranging from 707.9 nM to 0.7079 µM. It also shows significant antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells at a 10 µM concentration after 48 hours, with inhibition rates of 0.1% and -0.15%, respectively. The compound demonstrates 17.03% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. However, its IC50 value against SARS-CoV-2 in VERO-6 cells is greater than 19952.62 nM, indicating moderate to low potency. Additionally, a hit score of 0.1103 was reported in HRCE cells under specific conditions, suggesting potential efficacy. Moreover, Aklomide potently inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells at 10 µM with inhibition percentages of 100.21% and 115.49%, respectively. The compound also exhibits weak inhibition of the human BSEP transporter with an IC50 value greater than 1000000.0 nM, suggesting a limited effect on ATP-dependent [3H]-taurocholate transport. Lastly, in enzymatic assays for human HDAC6, it shows 8.11% and 3.17% inhibition using commercial and custom peptide substrates, respectively, indicating limited enzymatic inhibition activity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Aklomide (2-Chloro-4-nitrobenzamide) is used in poultry to treat parasites.
别名	阿克洛胺, Alkomide, 2-Chloro-4-nitrobenzamide

化学信息

分子量	200.58
分子式	C₇H₅ClN₂O₃
CAS No.	3011-89-0
Smiles	NC(=O)C1=C(Cl)C=C(C=C1)[N+]([O-])=O
密度	1.52 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (224.35 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (24.93 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9855 mL	24.9277 mL	49.8554 mL	249.2771 mL
5 mM	0.9971 mL	4.9855 mL	9.9711 mL	49.8554 mL
10 mM	0.4986 mL	2.4928 mL	4.9855 mL	24.9277 mL
20 mM	0.2493 mL	1.2464 mL	2.4928 mL	12.4639 mL
50 mM	0.0997 mL	0.4986 mL	0.9971 mL	4.9855 mL
100 mM	0.0499 mL	0.2493 mL	0.4986 mL	2.4928 mL