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Anti-C1 inhibitor Antibody (7X93)

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Anti-C1 inhibitor Antibody (7X93)
产品编号 TMAY-01438
别名 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

Anti-C1 inhibitor Antibody (7X93) 是一种 Rabbit 抗体,靶向 C1 inhibitor。Anti-C1 inhibitor Antibody (7X93) 可用于 WB,ELISA,ELISA(Det),IP。

Anti-C1 inhibitor Antibody (7X93)

Anti-C1 inhibitor Antibody (7X93)

Rating icon 还可以
Anti-C1 inhibitor Antibody (7X93)
产品编号 TMAY-01438 别名 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

Anti-C1 inhibitor Antibody (7X93) 是一种 Rabbit 抗体,靶向 C1 inhibitor。Anti-C1 inhibitor Antibody (7X93) 可用于 WB,ELISA,ELISA(Det),IP。

规格价格库存数量
20 μL
¥ 785
5日内发货
100 μL
¥ 2,294
5日内发货
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TargetMol 的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵守承诺用途,不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
化合物带有盐酸盐离子、硫酸盐离子等是否和其本身有什么区别?盐形式和游离态有什么区别?
盐和非盐形式化合物的活性分子是一样的,在生物实验中起到的效果也一致,活性和使用方法都是一样的。只是由于呈盐不同,物理性质比如溶解度会有差异。建议您根据溶解、实验需求进行选择。
如何选择某个靶点的特异性或总的抑制剂?特异性和非特异性的区别是什么?
抑制剂按照特异性分为广谱 pan 和特异性 selective 两种。Pan 为某个靶点总的抑制剂,对所有亚型或整个家族的成员都有抑制作用。Selective 抑制剂针对某个蛋白激酶的某个亚型或家族中某个成员抑制率特别高或有特异性抑制作用。 一般评价一个抑制剂的抑制效率主要看 IC50 值,IC50 值越低,说明抑制剂效率越高。建议您根据以上几个特征进行综合选择,也可联系技术帮您推荐相关抑制剂。
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产品介绍

生物活性
产品描述
Anti-C1 inhibitor Antibody (7X93) is a Rabbit antibody targeting C1 inhibitor. Anti-C1 inhibitor Antibody (7X93) can be used in WB,ELISA,ELISA(Det),IP.
别名serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Ig Type
Rabbit IgG
克隆号
7X93
交叉反应
Human
验证活性
1. SERPING1 was immunoprecipitated using:
-Lane A:0.5 mg HepG2 Whole Cell Lysate.
-2 µL anti-SERPING1 rabbit monoclonal antibody and 15 μl of 50 % Protein G agarose.
-Primary antibody:
-Anti-SERPING1 rabbit monoclonal antibody, at 1:100 dilution.
-Secondary antibody:
-Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution.
-Developed using the odyssey technique.
-Performed under reducing conditions.
-Predicted band size: 55 kDa.
-Observed band size: 100 kDa.
2. Anti-SerpinG1 rabbit monoclonal antibody at 1:500 dilution.
-Lane A: HepG2 Whole Cell lysate.
-Lysates/proteins at 30 μg per lane.
-Secondary
-Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.
-Developed using the Odyssey technique.
-Performed under reducing conditions.
-Predicted band size:55 kDa.
-Observed band size:71 kDa
应用
WB,ELISA,ELISA(Det),IP
推荐剂量
WB: 1:500-1:2000; ELISA: 1:5000-1:10000; IP: 0.5-2 μL/mg of lysate; ELISA(Det): 1:1000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinG1 (rh SerpinG1; TMPY-01183; NP_000053.2; Met 1-Ala 500).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Plasma protease C1 inhibitor, also known as C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPING1 and C1IN, is a serine proteinase inhibitor (serpin) that regulates activation of both the complement and contact systems. By its C-terminal part (serpin domain), characterized by three beta-sheets and an exposed mobile reactive loop, C1-INH binds, and blocks the activity of its target proteases. The N-terminal end (nonserpin domain) confers to C1-INH the capacity to bind lipopolysaccharides and E-selectin. Owing to this moiety, C1-INH intervenes in regulation of the inflammatory reaction. The heterozygous deficiency of C1-INH results in hereditary angioedema (HAE). Owing to its ability to modulate the contact and complement systems and the convincing safety profile, plasma-derived C1 inhibitor is an attractive therapeutic protein to treat inflammatory diseases other than HAE. Deficiency of C1 inhibitor results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa. C1 inhibitor may prove useful in a variety of other diseases including septic shock, reperfusion injury, hyperacute transplant rejection, traumatic and hemorrhagic shock, and the increased vascular permeability associated with thermal injury, interleukin-2 therapy and cardiopulmonary bypass.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
HRP
可提供抗体种类
2
抗原信息
免疫原
Recombinant Protein: Human SerpinG1 protein (TMPY-01183)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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