Dimercaprol

Name: Dimercaprol
Brand: TargetMol
SKU: T0781
Price: 145 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.64%

货号 T0781Cas号 59-52-9

别名 二巯基丙醇, 二巯丙醇, Dithiopropanol, Dicaptol

Dimercaprol (Dicaptol) 是一种具有抗HIV 活性的重金属中毒解毒剂。

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Dimercaprol

一键复制产品信息

很棒

纯度: 99.64%

货号 T0781 别名 二巯基丙醇, 二巯丙醇, Dithiopropanol, DicaptolCas号 59-52-9

Dimercaprol (Dicaptol) 是一种具有抗HIV 活性的重金属中毒解毒剂。

规格	价格	库存
10 mg	¥ 145	现货
25 mg	¥ 212	现货
50 mg	¥ 293	现货
100 mg	¥ 415	现货
500 mg	¥ 986	现货
1 g	¥ 1,450	现货
1 mL x 10 mM (in DMSO)	¥ 466	现货

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产品介绍

Dimercaprol AI Summary

Dimercaprol demonstrates a broad spectrum of bioactivities across various biological pathways and targets. It is potent in inhibiting the splicing of Lamin A, HSD17B4 (hydroxysteroid dehydrogenase 4), Tyrosyl-DNA Phosphodiesterase (TDP1), Aldehyde Dehydrogenase 1 (ALDH1A1), HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II), GCN5L2, Histone Lysine Methyltransferase G9a, 15-hLO-2 (15-human lipoxygenase 2), Vitamin D Receptor (VDR), and Glutaminase (GLS). Additionally, it shows inhibitory effects on Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase), Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), Human Flap endonuclease 1 (FEN1), and TGF-b. It also impacts the Cytochrome panel assay, particularly p450-cyp1a2, and impairs the function of the Influenza NS1 protein. In cellular models, Dimercaprol has demonstrated activity against the malarial parasite plastid, Lassa Virus, Marburg Virus, and Ebola Virus, as well as in various assays related to Schwann cells. Notably, it identifies gametocytocidal compounds and has dual action in Huntington's disease models. Furthermore, Dimercaprol inhibits NDM-1 (New Delhi metallo-beta-lactamase) with an IC50 value of 10400.0 nM using imipenem as a substrate and is involved in the activation of human PXR, leading to the induction of CYP3A4 with an efficacy of 35.5% and an EC50 value of 50100.0 nM. It exhibits competitive binding affinity to human PXR LBD and an 88.0% efficacy relative to SR12813 in a competitive binding assay. Importantly, Dimercaprol shows no significant impact on liver toxicity parameters, with scores recorded as 0.0 for various hepatic side effects according to the Drug Induced Liver Injury Prediction System (DILIps). Additionally, it exhibits inhibitory activity against various beta-lactamases (L1, CphA, IMP1, NDM1) from Aeromonas hydrophila ATCC 7966, suggesting potential antimicrobial properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Dimercaprol (Dicaptol) is an anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisonings.
别名	二巯基丙醇, 二巯丙醇, Dithiopropanol, Dicaptol

化学信息

分子量	124.22
分子式	C₃H₈OS₂
CAS No.	59-52-9
Smiles	OCC(S)CS
密度	1.239 g/cm3 at 25℃ (lit.)

储存&溶解度

存储

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (402.51 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.0502 mL	40.2512 mL	80.5023 mL	402.5117 mL
5 mM	1.6100 mL	8.0502 mL	16.1005 mL	80.5023 mL
10 mM	0.8050 mL	4.0251 mL	8.0502 mL	40.2512 mL
20 mM	0.4025 mL	2.0126 mL	4.0251 mL	20.1256 mL
50 mM	0.1610 mL	0.8050 mL	1.6100 mL	8.0502 mL
100 mM	0.0805 mL	0.4025 mL	0.8050 mL	4.0251 mL