Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,540 | 5日内发货 | ||
5 mg | ¥ 2,610 | 5日内发货 | ||
25 mg | ¥ 9,430 | 6-8周 | ||
50 mg | ¥ 12,253 | 6-8周 | ||
100 mg | ¥ 18,973 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,730 | 5日内发货 |
产品描述 | IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53. |
体外活性 | IRES-C11 (50 nM) significantly inhibits both cyclin D1 and c-MYC IRES activity. IRES-C11 treatment induces a significant shift in both cyclin D1 and c-MYC mRNA to monosomal/nonribosomal fractions, whereas actin mRNA distribution is unaffected. IRES-C11 inhibits both cyclin D1 and c-MYC IRES-mediated mRNA translation, leading to reductions in protein levels. Mechanistic studies with IRES-C11 reveal the binding of the inhibitors within the UP1 fragment of heterogeneous nuclear ribonucleoprotein A1.[1] |
别名 | IRES-C11 |
分子量 | 316.14 |
分子式 | C13H11Cl2NO4 |
CAS No. | 342416-30-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (711.7 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.1632 mL | 15.8158 mL | 31.6316 mL | 79.0789 mL |
5 mM | 0.6326 mL | 3.1632 mL | 6.3263 mL | 15.8158 mL | |
10 mM | 0.3163 mL | 1.5816 mL | 3.1632 mL | 7.9079 mL | |
20 mM | 0.1582 mL | 0.7908 mL | 1.5816 mL | 3.9539 mL | |
50 mM | 0.0633 mL | 0.3163 mL | 0.6326 mL | 1.5816 mL | |
100 mM | 0.0316 mL | 0.1582 mL | 0.3163 mL | 0.7908 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
IRES-C11 342416-30-2 Cell Cycle/Checkpoint c-Myc IRES-C-11 IRESC11 IRES C11 Inhibitor inhibitor inhibit