Memantine

Name: Memantine
Brand: TargetMol
SKU: T20993
Price: 142 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

货号 T20993Cas号 19982-08-2

Memantine 是口服具有活性的、非竞争性的N-甲基-D-天冬氨酸受体拮抗剂，可用于研究中重度阿尔茨海默病。

Memantine

一键复制产品信息

很棒

货号 T20993Cas号 19982-08-2

Memantine 是口服具有活性的、非竞争性的N-甲基-D-天冬氨酸受体拮抗剂，可用于研究中重度阿尔茨海默病。

规格	价格	库存
1 mg	¥ 142	现货
5 mg	¥ 287	现货
10 mg	¥ 407	现货
25 mg	¥ 665	现货
50 mg	¥ 981	现货
100 mg	¥ 1,460	现货
500 mg	¥ 3,550	现货

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实验操作小课堂

常见问题解答

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纯度: ≥98%

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COA MS HNMR 产品操作手册

产品介绍

Memantine AI Summary

Memantine exhibits a range of bioactivities across different biological targets. It acts as both an agonist and antagonist for the NFkB signaling pathway with a potency of 22.4 nM. It inhibits Cytochrome P450 enzymes including CYP2C19 with a potency of 10,000 nM, CYP2D6 with a potency of 316.2 nM, and shows considerable activity in Cytochrome panel assays for CYP2D6 (AC50 of 316.23 nM), CYP2C9 (AC50 of 19,952.62 nM), CYP1A2 (AC50 of 39,810.72 nM), and CYP2C19 (AC50 of 10,000.0 nM). Additionally, it inhibits the binding or entry of cells for the Marburg Virus with a potency of 20,587.8 nM, and inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells, showing potencies of 21,136.0 nM in the absence of CPT and 33,498.3 nM in its presence..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors.

化学信息

分子量	179.3
分子式	C₁₂H₂₁N
CAS No.	19982-08-2
Smiles	CC12CC3CC(C)(C1)CC(N)(C3)C2
密度	1.046

储存&溶解度

存储

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (1394.31 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.58 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5772 mL	27.8862 mL	55.7724 mL	278.8622 mL
5 mM	1.1154 mL	5.5772 mL	11.1545 mL	55.7724 mL
10 mM	0.5577 mL	2.7886 mL	5.5772 mL	27.8862 mL
20 mM	0.2789 mL	1.3943 mL	2.7886 mL	13.9431 mL
50 mM	0.1115 mL	0.5577 mL	1.1154 mL	5.5772 mL
100 mM	0.0558 mL	0.2789 mL	0.5577 mL	2.7886 mL