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Anti-Serpin A1 Antibody (6H814)
还可以产品编号 TMAY-00590
Anti-Serpin A1 Antibody (6H814) 是一种 Rabbit 抗体，靶向 Serpin A1。Anti-Serpin A1 Antibody (6H814) 可用于 ELISA。
Anti-Serpin A1 Antibody (6H814)
Anti-Serpin A1 Antibody (6H814)
还可以产品编号 TMAY-00590
Anti-Serpin A1 Antibody (6H814) 是一种 Rabbit 抗体，靶向 Serpin A1。Anti-Serpin A1 Antibody (6H814) 可用于 ELISA。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Serpin A1 Antibody (6H814) is a Rabbit antibody targeting Serpin A1. Anti-Serpin A1 Antibody (6H814) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 6H814 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinA1 (rh SerpinA1; TMPY-00915; NP_000286.3; Met 1-Lys 418). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antitrypsin is mainly produced in the liver and acts as an antiprotease. Its principal function is to inactivate neutrophil elastase, preventing tissue damage. SerpinA1 (alpha1-antitrypsin), an acute phase protein and the classical neutrophil elastase inhibitor, is localized within lipid rafts in primary human monocytes in vitro. Its association with monocytes is inhibited by cholesterol depleting/efflux-stimulating agents (nystatin, filipin, MbetaCD (methyl-beta-cyclodextrin) and oxidized low-density lipoprotein (oxLDL) and conversely, enhanced by free cholesterol. Furthermore, SerpinA1/monocyte association per se depletes lipid raft cholesterol as characterized by the activation of extracellular signal-regulated kinase 2, formation of cytosolic lipid droplets, and complete inhibition of oxLDL uptake by monocytes. Previous population studies have suggested that heterozygote status for the AAT gene (SerpinA1) is a risk factor for chronic rhinosinusitis with nasal polyposis (CRSwNP). Alpha-1 antitrypsin deficiency is a recently identified genetic disease that occurs almost as frequently as cystic fibrosis. It is caused by various mutations in the SerpinA1 gene, and has numerous clinical implications. Alpha-1 antitrypsin deficiency is an inherited disease affecting the lung and liver. In the liver, alpha-1 antitrypsin deficiency may manifest as benign neonatal hepatitis syndrome; a small percentage of adults develop liver fibrosis, with progression to cirrhosis and hepatocellular carcinoma. Its most important physiologic functions are the protection of pulmonary tissue from aggressive proteolytic enzymes and regulation of pulmonary immune processes. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human SerpinA1 protein (TMPY-00915) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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