GLYCODEOXYCHOLIC ACID

Name: GLYCODEOXYCHOLIC ACID
Brand: TargetMol
SKU: T5352
Price: 119 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.89%

货号 T5352Cas号 360-65-6

别名 甘氨脱氧胆酸

Glycodeoxycholic Acid 是内源性代谢产物的一种,是一种存在于黑链霉菌、布氏锥虫和隐单胞菌中的天然产物,可诱导阻塞性胆汁淤积症患者的肝细胞坏死和自噬。

GLYCODEOXYCHOLIC ACID

一键复制产品信息

很棒

纯度: 99.89%

货号 T5352 别名 甘氨脱氧胆酸Cas号 360-65-6

规格	价格	库存
25 mg	¥ 159	现货
50 mg	¥ 222	现货
100 mg	¥ 313	现货
500 mg	¥ 743	现货
1 g	¥ 1,090	现货
1 mL x 10 mM (in DMSO)	¥ 119	现货

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

GLYCODEOXYCHOLIC ACID AI Summary

GLYCODEOXYCHOLIC ACID exhibits multiple biological activities and properties. It demonstrates agonist activity at human TGR5 expressed in CHO cells, with an EC50 of 1180 nM and an efficacy relative to lithocholic acid of 105%. The compound also shows cytotoxicity against human HET-1A and HuH7 cells, as revealed by the MTT assay. Specifically, at 500 µM after 24 hours, it is 1.113% cytotoxic for HET-1A cells with a CC50 value of 1,237,000 nM, and 1.05% cytotoxic for HuH7 cells. Furthermore, GLYCODEOXYCHOLIC ACID has a notable interaction with transporter proteins, showing uptake in ASBT-expressing COS cells (Km = 2000 nM) and in Oatp3-expressing MDCK cells (Km = 4300 nM). Additionally, it inhibits the uptake of estrone sulfate by 53.8% via human liver OATP2B1, estradiol-17β-glucuronide (E17βG) by 79% through OATP1B3, and E17βG by 85% via OATP1B1. These characteristics suggest that GLYCODEOXYCHOLIC ACID may have significant implications in transporter-mediated bioactivity and receptor modulation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Glycodeoxycholic Acid is an endogenous metabolite, a natural product found in Streptomyces niger, Trypanosoma brucei, and Cryptomonas, which induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis.
别名	甘氨脱氧胆酸

化学信息

分子量	449.62
分子式	C₂₆H₄₃NO₅
CAS No.	360-65-6
Smiles	[H][C@@]12CC[C@H]([C@H](C)CCC(=O)NCC(O)=O)[C@@]1(C)[C@@H](O)C[C@@]1([H])[C@@]2([H])CCC2C[C@H](O)CC[C@]12C
密度	1.162 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 126 mg/mL (280.24 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.9 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2241 mL	11.1205 mL	22.2410 mL	111.2050 mL
5 mM	0.4448 mL	2.2241 mL	4.4482 mL	22.2410 mL
10 mM	0.2224 mL	1.1121 mL	2.2241 mL	11.1205 mL
20 mM	0.1112 mL	0.5560 mL	1.1121 mL	5.5603 mL
50 mM	0.0445 mL	0.2224 mL	0.4448 mL	2.2241 mL
100 mM	0.0222 mL	0.1112 mL	0.2224 mL	1.1121 mL