Name: Zaurategrast
Brand: TargetMol
SKU: T17286
Price: 546 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 546

现货

5 mg

¥ 2,199

现货

生物活性

产品描述	Zaurategrast (CDP323) is a small-molecule prodrug antagonist that inhibits the interaction between vascular cell adhesion molecule 1 (VCAM-1) and α4-integrins, originally developed by Celltech plc for oral administration, and it serves as a valuable research compound for investigating leukocyte trafficking, immune cell adhesion, and therapeutic strategies relevant to multiple sclerosis.
靶点活性	α4-integrin:< 100 nM
体外活性	方法：通过体外通透性和摄取实验以及在小鼠、大鼠、犬和食蟹猴中的体内研究评估 Zaurategrast 的药代动力学特性，并进一步评价其乙酯前药。结果：由于吸收不良和肝脏主动摄取，Zaurategrast 在啮齿类和猴中的口服生物利用度较低；其前药 CDP323 改善了通透性和口服生物利用度，并可在体内有效转化[1]。
别名	札雷司特, Zaurategrast, CT-7758, CT7758, CT 7758

化学信息

分子量	521.41
分子式	C₂₆H₂₅BrN₄O₃
CAS No.	455264-31-0
Smiles	N([C@@H](CC1=CC=C(NC=2C3=C(C=CN2)C=CN=C3)C=C1)C(O)=O)C=4C5(C(=O)C4Br)CCCCC5
密度	1.31g/cm3

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (153.43 mM), Sonication is recommended.

溶液配制表

DMSO

Zaurategrast