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Isoxepac

Name: Isoxepac
Brand: TargetMol
SKU: T27635
Price: 145 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.86%

货号 T27635Cas号 55453-87-7

别名 伊索克酸, Olopatadine USP Related Compound C

Isoxepac (Olopatadine USP Related Compound C) 是非甾体抗炎剂，显示出抗炎、镇痛和解热活性，已在多种动物模型中进行了相关研究。

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Isoxepac

一键复制产品信息

很棒

纯度: 99.86%

货号 T27635 别名 伊索克酸, Olopatadine USP Related Compound CCas号 55453-87-7

Isoxepac (Olopatadine USP Related Compound C) 是非甾体抗炎剂，显示出抗炎、镇痛和解热活性，已在多种动物模型中进行了相关研究。

规格	价格	库存
50 mg	¥ 145	现货
100 mg	¥ 193	现货
500 mg	¥ 417	现货
1 g	¥ 588	现货
5 g	¥ 1,460	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.86%

颜色: 黄色

性状: Solid

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COA LCMS HNMR 产品操作手册

产品介绍

Isoxepac AI Summary

Isoxepac exhibits a broad spectrum of bioactivities, notably including anti-inflammatory, analgesic, antiviral, and enzyme inhibitory properties. It reduces paw edema induced by carrageenan in rat models with an ED50 ranging from 6.36 mg/kg to 50.0 umol.kg-1, demonstrating significant efficacy in inflammatory conditions. It also shows inhibition of 5-lipoxygenase and reduction of 5-HETE levels by 1.5%. Additionally, it possesses analgesic activities by inhibiting phenylquinone-induced writhing in mice and reducing arachidonic acid oedema in mouse ears with an ED50 of 55.0 mg ear-1. However, its usage is associated with gastric irritation in rats, indicating some gastrointestinal toxicity with an ID50 of 82.47 mg/kg and a therapeutic index of 13.0. Moreover, Isoxepac has notable antiviral activities, inhibiting SARS-CoV-2-induced cytotoxicity in both Caco-2 and VERO-6 cells at 10 uM concentration, with varying efficacy across different assays. It also demonstrates inhibitory activity against the SARS-CoV-2 3CL-Pro protease and blocks the entry of the Ebola virus. Additionally, the compound is a potent inhibitor of human HDAC6, showing inhibition rates as high as 75.05% in enzymatic assays with specific substrates. Overall, Isoxepac presents a multifaceted bioactivity profile with potential therapeutic applications in anti-inflammatory and antiviral treatments, alongside notable enzyme inhibition properties, albeit with some associated toxicities..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Isoxepac (Olopatadine USP Related Compound C) is a non-steroidal anti-antiphlogistic agent and analgesic.
别名	伊索克酸, Olopatadine USP Related Compound C

化学信息

分子量	268.26
分子式	C₁₆H₁₂O₄
CAS No.	55453-87-7
Smiles	O=C1C=2C(OCC=3C1=CC=CC3)=CC=C(CC(O)=O)C2
密度	1.349 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (167.75 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.46 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7277 mL	18.6386 mL	37.2773 mL	186.3863 mL
5 mM	0.7455 mL	3.7277 mL	7.4555 mL	37.2773 mL
10 mM	0.3728 mL	1.8639 mL	3.7277 mL	18.6386 mL
20 mM	0.1864 mL	0.9319 mL	1.8639 mL	9.3193 mL
50 mM	0.0746 mL	0.3728 mL	0.7455 mL	3.7277 mL
100 mM	0.0373 mL	0.1864 mL	0.3728 mL	1.8639 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。