Famotidine

Name: Famotidine
Brand: TargetMol
SKU: T1627
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.91%

货号 T1627Cas号 76824-35-6

别名 法莫替丁, MK-208

Famotidine (MK-208) 是一种具有抗酸活性的丙脒和组胺 H2 受体拮抗剂。

Famotidine

一键复制产品信息

很棒

纯度: 99.91%

货号 T1627 别名 法莫替丁, MK-208Cas号 76824-35-6

Famotidine (MK-208) 是一种具有抗酸活性的丙脒和组胺 H2 受体拮抗剂。

规格	价格	库存	数量
2 g	¥ 108	现货

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COA LCMS HNMR 产品操作手册

产品介绍

Famotidine AI Summary

Famotidine exhibits a range of bioactivities including inhibitory effects against HIV-1 integrase, with inhibition results of less than 50.0% at both 1 mM and 200 µM concentrations. It acts as a histamine H2 receptor antagonist, demonstrated by its ability to reduce the chronotropic response to histamine in guinea pig right atrium with an ED50 of 0.0000027 M and reduction in gastric acid secretion in anesthetized dogs with an ED50 of 0.0087 mg/kg. The compound has a binding affinity (Kd) of 18.2 nM on isolated guinea pig right atrium and shows efficacy in inhibiting various gastric functions including aspirin-induced gastric lesions and gastric acid secretion in rats. Famotidine exhibits an absorption rate of 45.0% in the human GI tract, a logD6.8 of -0.8, and a bioavailability of 49.0%. It also has a total body clearance rate of 6.6 mL/min/kg in humans, with renal clearance rate of 4.42 mL/min/kg, and exhibits an ionization constant (pKa) of 7.1. The compound demonstrates moderate protein binding with a logFu of 0.83 and a volume of distribution at steady state (Vdss) of 1.2 L/kg. Famotidine also shows various other bioactivities including antiviral, antifungal, and antibacterial activities, selective inhibition of human MATE1-mediated transport, liver toxicity, and potential as a histamine H2 radioligand binding antagonist. Additionally, it affects markers of liver function, kidney function, electrolyte balance, glucose levels, and lipid metabolism, suggesting diverse bioactivities affecting multiple physiological systems. Its inhibitory activity includes significant bioactivities towards different enzymes such as Bloom's syndrome helicase, Histone Lysine Methyltransferase G9a, Bacillus subtilis Sfp phosphopantetheinyl transferase, and others, indicating potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Famotidine (MK-208) is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors located on the basolateral membrane of the parietal cell, famotidine reduces basal and nocturnal gastric acid secretion, resulting in a reduction in gastric volume, acidity, and amount of gastric acid released in response to various stimuli.
别名	法莫替丁, MK-208

化学信息

分子量	337.45
分子式	C₈H₁₅N₇O₂S₃
CAS No.	76824-35-6
Smiles	N(C(=N)N)C1=NC(CSCCC(NS(N)(=O)=O)=N)=CS1
密度	1.5111 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (740.85 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.93 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9634 mL	14.8170 mL	29.6340 mL	148.1701 mL
5 mM	0.5927 mL	2.9634 mL	5.9268 mL	29.6340 mL
10 mM	0.2963 mL	1.4817 mL	2.9634 mL	14.8170 mL
20 mM	0.1482 mL	0.7409 mL	1.4817 mL	7.4085 mL
50 mM	0.0593 mL	0.2963 mL	0.5927 mL	2.9634 mL
100 mM	0.0296 mL	0.1482 mL	0.2963 mL	1.4817 mL