store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IM-156 acetate 是一种 NADH 脱氢酶(IC50=2.2μM)和 AMP-激活蛋白激酶α(AMPKα)的激活剂,是一种可口服且具有生物利用的线粒体氧化磷酸化(OxPhos)抑制剂。IM-156 acetate 可增加 AMPKα活性,抑制氯己酮诱导的大鼠腹膜纤维化,抑制肿瘤生长 。
产品描述 | IM-156 acetate, an activator of NADH dehydrogenase (IC50=2.2 μM) and AMP-activated protein kinase alpha (AMPKα), is an orally available and bioavailable inhibitor of mitochondrial oxidative phosphorylation (OxPhos).IM-156 acetate increases AMPKα activity and inhibits chlorhexadiene-induced peritoneal fibrosis and inhibit tumor growth in rats . |
靶点活性 | OCR:3.3 µM, NADH dehydrogenase:2.2 µM |
体外活性 | IM-156 is an inhibitor of mitochondrial complex I, also known as an activator of NADH dehydrogenase (IC50 = 2.2 µM) and AMP-activated protein kinase α (AMPKα).[1][2] |
体内活性 | It reduces the oxygen consumption rate (OCR; IC50 = 3.3 µM) and decreases mitochondrial ATP production in Eµ-Myc mouse lymphoma cells.1 IM-156 (10, 30, and 50 µM) increases AMPKα activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg.2 It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.[3][4] |
别名 | HL271 acetate |
分子量 | 375.35 |
分子式 | C15H20F3N5O3 |
CAS No. | 2043654-54-0 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1.0mg/mL (3.2mM)
DMF: 1.0mg/mL (3.2mM)
Ethanol: 1 mg/mL
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / DMF | 1 mM | 2.6642 mL | 13.3209 mL | 26.6418 mL | 66.6045 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
IM-156 acetate 2043654-54-0 HL271 Acetate IM-156 Acetate IM156 Acetate HL-271 Acetate IM 156 Acetate HL 271 Acetate HL271 acetate Inhibitor inhibitor inhibit