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顶部相关产品产品介绍化学信息储存和溶解信息计算器

3,5-Dimethoxystilbene

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纯度: 98.39%

货号 TN7115Cas号 21956-56-9

别名 cis-Pinosylvin dimethyl ether, 3,5-二甲氧基二苯乙烯

3,5-Dimethoxystilbene (cis-Pinosylvin dimethyl ether) 是一种从短叶松 Pinus bunksiuna 树皮中分离出来的天然产物。

3,5-Dimethoxystilbene

3,5-Dimethoxystilbene

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Rating icon 很棒

纯度: 98.39%

货号 TN7115 别名 cis-Pinosylvin dimethyl ether, 3,5-二甲氧基二苯乙烯Cas号 21956-56-9

3,5-Dimethoxystilbene (cis-Pinosylvin dimethyl ether) 是一种从短叶松 Pinus bunksiuna 树皮中分离出来的天然产物。

规格价格库存数量
10 mg
¥ 108
现货
25 mg
待询
现货
50 mg
待询
现货
1 mL x 10 mM (in DMSO)
¥ 195
现货
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纯度: 98.39%
颜色: 白色
性状: Solid
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产品介绍

3,5-Dimethoxystilbene AI Summary
3,5-Dimethoxystilbene exhibits a diverse range of bioactivities across various biological assays and targets. It inhibits the production of PGE-2 in LPS-stimulated RAW264.7 cells with an IC50 value of 100.0 nM and has larvicidal activity against Aedes aegypti larvae at a minimum concentration of 3.0 ppm, achieving complete larval mortality within 24 hours. The compound shows antimicrobial activity, though it is not highly effective against certain bacteria strains such as Mycobacterium smegmatis, Escherichia coli, Bacillus cereus, methicillin-resistant Staphylococcus aureus, and Staphylococcus aureus, with MIC values greater than 512.0 ug/mL. 3,5-Dimethoxystilbene also displays potency in several biochemical assays, including inhibition of JMJD2A-Tudor Domain, Nrf2 activation, HP1-beta Chromodomain interactions, polymerase iota, and mammalian selenoprotein thioredoxin reductase 1 (TrxR1). It inhibits Marburg Virus binding or entry into cells and induces DNA re-replication in MCF 10a breast cells and SW480 colon adenocarcinoma cells. Additionally, it modulates PINK1 expression, inhibits the SWI/SNF chromatin remodeling complex, and acts as an agonist of the gsp mutation responsible for Fibrous Dysplasia/McCune-Albright Syndrome. The compound inhibits Electrophorus electricus C2888 AChE with an IC50 value of 9,000.0 nM and exhibits dual activity at human and rat TRPA1 receptors. It acts as an antagonist at human TRPV1 receptors (IC50 > 10,000.0 nM) and also performs as both an agonist (EC50 of 1,700.0 nM, efficacy of 84.1%) and antagonist (IC50 of 3,400.0 nM) at rat TRPA1 receptors. Furthermore, it shows inhibition of TRPA1 activity at 30 µM, preincubated for 6 minutes, resulting in decreased AITC-induced calcium influx, while also inducing calcium influx under similar conditions. Characterized by a log P value of 4.15, 3,5-Dimethoxystilbene has high lipophilicity, which could influence its bioavailability, distribution, and interaction with biological systems..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
3,5-Dimethoxystilbene (cis-Pinosylvin dimethyl ether) is a natural product isolated from the bark of jack pine (Pinus bunksiuna).
别名cis-Pinosylvin dimethyl ether, 3,5-二甲氧基二苯乙烯
化学信息
分子量240.3
分子式C16H16O2
CAS No.21956-56-9
SmilesCOc1cc(OC)cc(\C=C\c2ccccc2)c1
密度1.1228 g/cm3 (Estimated)
储存&溶解度
存储
溶解度信息
DMSO: 50 mg/mL (208.07 mM), Sonication is recommended.
体内实验配方
10% DMSO+90% Corn Oil: 2.5 mg/mL (10.4 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM4.1615 mL20.8073 mL41.6146 mL208.0732 mL
5 mM0.8323 mL4.1615 mL8.3229 mL41.6146 mL
10 mM0.4161 mL2.0807 mL4.1615 mL20.8073 mL
20 mM0.2081 mL1.0404 mL2.0807 mL10.4037 mL
50 mM0.0832 mL0.4161 mL0.8323 mL4.1615 mL
100 mM0.0416 mL0.2081 mL0.4161 mL2.0807 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

Pinus bunksiunajack pineInhibitorinhibitbenzene extract3,5-Dimethoxystilbene3,5Dimethoxystilbene3,5 Dimethoxystilbene
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