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Xanthurenic Acid

Name: Xanthurenic Acid
Brand: TargetMol
SKU: T3010
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 黄尿酸, xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid

货号 T3010Cas号 59-00-7 一键复制产品信息纯度: 99.66%

很棒

Xanthurenic Acid (8-Hydroxykynurenic acid) 是通过 3-羟基犬尿氨酸转氨而由色氨酸代谢产生的分子，可激活 mGlu2/3 代谢型谷氨酸受体。在下丘脑的感觉传输过程中，它被认为是Group II 代谢型谷氨酸受体的激动剂。

Xanthurenic Acid

一键复制产品信息

很棒

纯度: 99.66%

货号 T3010Cas号 59-00-7

别名 黄尿酸, xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid

规格	价格	库存
25 mg	¥ 198	现货
50 mg	¥ 289	现货
100 mg	¥ 415	现货
500 mg	¥ 986	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.66%

性状: Solid

资源下载: COA HPLC HNMR产品操作手册

产品介绍

Xanthurenic Acid AI Summary

Xanthurenic Acid exhibits a diverse range of bioactivities across multiple biological targets. It competitively inhibits the Vesicular glutamate transporter (VGLUT) with a Ki value of 190,000 nM and shows 4.0% inhibitory activity against vesicular glutamate transport (GVT) in synaptic vesicles isolated from rat forebrain. In various inhibitory assays, Xanthurenic Acid demonstrates potencies against several targets: Human Jumonji Domain Containing 2E (JMJD2E) with potencies of 17782.8 nM and 10000.0 nM, Tyrosyl-DNA Phosphodiesterase (TDP1) at 12589.3 nM, Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) at 79432.8 nM, Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia at 9976.3 nM, JMJD2A-Tudor Domain at 28183.8 nM, and HP1-beta Chromodomain Interactions with Methylated Histone Tails at 100000.0 nM. It also inhibits human plasma lipoprotein-associated phospholipase A2 with an IC50 value exceeding 100,000 nM. Moreover, Xanthurenic Acid exhibits a strong inhibitory effect on sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, with inhibition percentages of 99.4% and 115.8%, respectively, at an equimolar concentration of 10 µM. It also displays antiallergic activity with an ED50 of 114.0 µmol.kg^-1 and an activity index of 9.1 in Sprague-Dawley rats. Additionally, Xanthurenic Acid shows antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in VERO-6 cells, with an IC50 greater than 20000.0 nM at 10 µM concentration after 48 hours exposure to the SARS-CoV-2 virus, suggesting its potential as an antiviral candidate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Xanthurenic Acid (8-Hydroxykynurenic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3).
别名	黄尿酸, xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid

化学信息

分子量	205.17
分子式	C₁₀H₇NO₄
CAS No.	59-00-7
Smiles	OC(=O)c1cc(O)c2cccc(O)c2n1
密度	1.569g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 2.05 mg/mL (9.99 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8740 mL	24.3700 mL	48.7401 mL	243.7003 mL
5 mM	0.9748 mL	4.8740 mL	9.7480 mL	48.7401 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Xanthurenic Acid mGluR Metabotropic glutamate receptors Inhibitor inhibit GluR EndogenousMetabolite Endogenous Metabolite Apoptosis

Xanthurenic Acid

Xanthurenic Acid