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NS1643

Name: NS1643
Brand: TargetMol
SKU: T3192
Price: 132 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.31%

货号 T3192Cas号 448895-37-2

NS1643 是一种有效的人类 ether-a-go-go 相关基因 (hERG) KV11.1 通道激活剂，EC50 为 10.5 μM。它增加了复极保留，展示出新型抗心律失常的方法。它通过减少通道失活，在高浓度下，对 erg2 (Kv11.2) 电流有明显影响。

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NS1643

一键复制产品信息

很棒

纯度: 99.31%

货号 T3192Cas号 448895-37-2

规格	价格	库存
1 mg	¥ 132	现货
5 mg	¥ 277	现货
10 mg	¥ 453	现货
25 mg	¥ 956	现货
50 mg	¥ 1,580	现货
100 mg	¥ 2,630	现货
1 mL x 10 mM (in DMSO)	¥ 297	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.31%

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产品介绍

NS1643 AI Summary

NS1643 exhibits a broad spectrum of bioactivities acting as an inhibitor of diverse molecular targets. It has demonstrated potency in inhibiting ROR gamma transcriptional activity, aiming at the Menin-MLL interaction in MLL-related leukemias, inhibiting GCN5L2, and obstructing the interaction between CBF-beta and RUNX1 for treating Acute Myeloid Leukemia. Furthermore, the compound shows antiviral properties by reducing SARS-CoV-2 induced cytotoxicity in various cell lines, including Caco-2 and VERO-6 cells, although the inhibition rates observed in certain assays were relatively low. Additionally, it has shown activity against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells, albeit with a hit score below the considered threshold for significant on-disease activity. NS1643 was also tested for its ability to inhibit the SARS-CoV-2 3CL-Pro protease and human HDAC6 enzyme, where it exhibited marginal to negative inhibitory effects. The compound demonstrates varied potencies across these different biological assessments..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.
靶点活性	ERG (human):10.5 μM(EC50)

化学信息

分子量	380.24
分子式	C₁₅H₁₀F₆N₂O₃
CAS No.	448895-37-2
Smiles	Oc1ccc(cc1NC(=O)Nc1cc(ccc1O)C(F)(F)F)C(F)(F)F
密度	1.626 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (131.5 mM), Sonication is recommended.

Ethanol: 100 mM, Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.26 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6299 mL	13.1496 mL	26.2992 mL	131.4959 mL
5 mM	0.5260 mL	2.6299 mL	5.2598 mL	26.2992 mL
10 mM	0.2630 mL	1.3150 mL	2.6299 mL	13.1496 mL
20 mM	0.1315 mL	0.6575 mL	1.3150 mL	6.5748 mL
50 mM	0.0526 mL	0.2630 mL	0.5260 mL	2.6299 mL
100 mM	0.0263 mL	0.1315 mL	0.2630 mL	1.3150 mL