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Hexetidine

Name: Hexetidine
Brand: TargetMol
SKU: T0328
Price: 133 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.48%

货号 T0328Cas号 141-94-6

别名 海克替啶, NSC-17764

Hexetidine (NSC-17764) 是一种口服活性的抗菌抗真菌试剂，可用于口腔感染的相关研究。

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Hexetidine

一键复制产品信息

很棒

纯度: 97.48%

货号 T0328 别名 海克替啶, NSC-17764Cas号 141-94-6

Hexetidine (NSC-17764) 是一种口服活性的抗菌抗真菌试剂，可用于口腔感染的相关研究。

规格	价格	库存
2 mg	¥ 133	现货
5 mg	¥ 193	现货
10 mg	¥ 265	现货
25 mg	¥ 417	现货
50 mg	¥ 667	现货
100 mg	¥ 976	现货
500 mg	¥ 2,420	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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COA LCMS HNMR 产品操作手册

产品介绍

Hexetidine AI Summary

Hexetidine exhibits a broad spectrum of bioactivities according to various assays. It induces a relaxation effect of -94.0% on isolated guinea pig trachea and demonstrates specificity in erasing genomic imprints with a potency of 5011.9 nM. It inhibits human tyrosyl-DNA phosphodiesterase 1 with potencies ranging from 163.6 nM to 16360.1 nM, depending on the presence of CPT. Additionally, it inhibits Vaccinia Orthopoxvirus with NCI-H293-values of 31622.8 nM and 14125.4 nM and blocks Ebola Virus entry with an AC50 of 3981.1 nM. It inhibits GLP1 secretion from STC-1 cells and NCI-H716 cells with respective IC50 values of 26572.9 nM and 36442.2 nM. At a concentration of 10 μM, Hexetidine inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells by 75.93% and 102.13%, respectively. However, it showed low activity in inhibiting cell viability in SARS-CoV-2-infected Vero E6 cells with an inhibition index of -0.1045, suggesting limited efficacy in this context. The compound also exhibits binding affinity to human receptors and transporters such as DRD1, KCNH2, and various SLC6 transporters, among others. It acts as an antagonist at TBXA2R and as an agonist at ADRA3 and CHRM1. Despite being evaluated against several human enzymes, including ACHE and MAOA, it demonstrated weak or no inhibitory effects, with AC50 values generally above 30000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Hexetidine (NSC-17764) is a bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene.
别名	海克替啶, NSC-17764

化学信息

分子量	339.61
分子式	C₂₁H₄₅N₃
CAS No.	141-94-6
Smiles	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1
密度	0.889g/mLat 25°C(lit.)

储存&溶解度

存储

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 75 mg/mL (220.84 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.89 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9446 mL	14.7228 mL	29.4455 mL	147.2277 mL
5 mM	0.5889 mL	2.9446 mL	5.8891 mL	29.4455 mL
10 mM	0.2945 mL	1.4723 mL	2.9446 mL	14.7228 mL
20 mM	0.1472 mL	0.7361 mL	1.4723 mL	7.3614 mL
50 mM	0.0589 mL	0.2945 mL	0.5889 mL	2.9446 mL
100 mM	0.0294 mL	0.1472 mL	0.2945 mL	1.4723 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。