Name: Lumicitabine
Brand: TargetMol
SKU: TQ0034
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

2 mg

¥ 1,820

5日内发货

5 mg

¥ 2,890

5日内发货

10 mg

¥ 4,160

5日内发货

1 mL x 10 mM (in DMSO)

¥ 2,780

5日内发货

产品介绍

生物活性

产品描述	Lumicitabine (ALS-008176) is an inhibitor of RSV polymerase.
体内活性	In an adult human challenge study, Lumicitabine has shown efficacy against RSV infection[1]. Lumicitabine solubility is adequate to support oral administration in solutions with a relatively low percentage of organic solvent and in aqueous suspensions. High levels of NMP and NTP are obtained following the oral administration of Lumicitabine to monkeys [2].
动物实验	Rats: Lumicitabine is formulated as solutions in PEG400-based vehicles. Pharmacokinetic studies are conducted at 5 mg/kg and for oral PK studies, the prodrugs are administered at 5 mg/kg parent nucleoside equivalent doses. Blood samples are typically collected at various time points up to 24 h post dose for rat [2]. Monkeys: Lumicitabine is formulated as a solution in PEG400-based vehicles. Pharmacokinetic studies are conducted at 5 mg/kg and for oral PK studies, the prodrugs are administered at 5 mg/kg parent nucleoside equivalent doses. Blood samples are typically collected at various time points up to 12 h post dose for Monkeys [2].
别名	ALS-8176, ALS-008176

化学信息

分子量	433.86
分子式	C₁₈H₂₅ClFN₃O₆
CAS No.	1445385-02-3
密度	1.43 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 48 mg/mL (110.63 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3049 mL	11.5245 mL	23.0489 mL	115.2445 mL
5 mM	0.4610 mL	2.3049 mL	4.6098 mL	23.0489 mL
10 mM	0.2305 mL	1.1524 mL	2.3049 mL	11.5245 mL
20 mM	0.1152 mL	0.5762 mL	1.1524 mL	5.7622 mL
50 mM	0.0461 mL	0.2305 mL	0.4610 mL	2.3049 mL
100 mM	0.0230 mL	0.1152 mL	0.2305 mL	1.1524 mL

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH₂O，那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300/ PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

Lumicitabine

Lumicitabine

产品介绍

计算器

体内实验配液计算器

剂量转换

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