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Trihexyphenidyl hydrochloride

Name: Trihexyphenidyl hydrochloride
Brand: TargetMol
SKU: T7002
Price: 220 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.65%

货号 T7002Cas号 52-49-3

别名 盐酸苯海索, Triesifenidile, Tremin, Benzhexol hydrochloride, Artane hydrochloride

Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) 是一种抗毒蕈碱类的抗帕金森病药物，结合至M1毒蕈碱受体。

Trihexyphenidyl hydrochloride

一键复制产品信息

很棒

纯度: 99.65%

货号 T7002 别名 盐酸苯海索, Triesifenidile, Tremin, Benzhexol hydrochloride, Artane hydrochlorideCas号 52-49-3

Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) 是一种抗毒蕈碱类的抗帕金森病药物，结合至M1毒蕈碱受体。

规格	价格	库存
100 mg	¥ 220	现货
500 mg	¥ 418	现货
1 mL x 10 mM (in DMSO)	¥ 242	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.65%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Trihexyphenidyl hydrochloride AI Summary

Trihexyphenidyl hydrochloride exhibits a wide range of biological activities across various assays. It shows potent binding affinity for human muscarinic receptors M1, M2, M3, M4, and M5, with IC50 values of 1.3 nM, 18.6 nM, 26.3 nM, 6.7 nM, and 10.3 nM, respectively, indicating its potential effects on muscarinic receptor-mediated pathways. The compound also demonstrates antiplasmodial activity against Plasmodium falciparum strains, with IC50 values from 2511.89 nM to 12589.25 nM. Additionally, it shows effectiveness in inhibiting proliferation of various Plasmodium falciparum lines (IC50 ranging from 3162.3 nM to 18526.0 nM). In antiviral assays, Trihexyphenidyl hydrochloride inhibits the entry of Lassa and Marburg viruses (potency ranging from 11220.2 nM to 23109.3 nM) and demonstrates inhibitory effects on SARS-CoV-2. It shows inhibition of SARS-CoV-2-induced cytotoxicity in Caco-2 cells and Vero E6 cells, with moderate activity levels. Specifically, it inhibits SARS-CoV-2 3CL-Pro protease by 6.361% at 20µM concentration. The compound also has significant inhibitory effects on OATP1B1 and OATP1B3 in CHO cells, with inhibition percentages of 83.05% and 73.95% at 10 µM, suggesting strong inhibition of sodium fluorescein uptake. In terms of antibacterial activity, Trihexyphenidyl hydrochloride exhibits moderate to strong inhibition against various bacterial strains, including Escherichia coli (7.07%), Klebsiella pneumoniae (14.55%), Pseudomonas aeruginosa (14.72%), Acinetobacter baumannii (37.84%), and Staphylococcus aureus MRSA (17.03%). It also shows some antifungal activity, with 4.22% inhibition of Candida albicans but minimal activity against Cryptococcus neoformans. Overall, Trihexyphenidyl hydrochloride demonstrates potential as a multi-functional agent with significant antimalarial, antiviral, and antibacterial properties, alongside notable activity on human muscarinic receptors..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is an antiparkinsonian agent of the antimuscarinic class.
别名	盐酸苯海索, Triesifenidile, Tremin, Benzhexol hydrochloride, Artane hydrochloride

化学信息

分子量	337.927
分子式	C₂₀H₃₂ClNO
CAS No.	52-49-3
Smiles	Cl.OC(CCN1CCCCC1)(C1CCCCC1)c1ccccc1
密度	0.9801 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 23 mg/mL (68.06 mM), Sonication is recommended.

DMSO: 13 mg/mL (38.47 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.9592 mL	14.7961 mL	29.5922 mL	147.9610 mL
5 mM	0.5918 mL	2.9592 mL	5.9184 mL	29.5922 mL
10 mM	0.2959 mL	1.4796 mL	2.9592 mL	14.7961 mL
20 mM	0.1480 mL	0.7398 mL	1.4796 mL	7.3980 mL

Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.0592 mL	0.2959 mL	0.5918 mL	2.9592 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Trihexyphenidyl Hydrochloride Trihexyphenidyl Parkinson disease neuronal Muscarinic acetylcholine receptor mAChR Inhibitor inhibit dystonia Cholinesterase (ChE)Benzhexol Hydrochloride Artane Hydrochloride anti-M1 muscarinic activity AChR 58947-95-8

Trihexyphenidyl hydrochloride

Trihexyphenidyl hydrochloride