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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Trihexyphenidyl hydrochloride

Synonyms: 盐酸苯海索, Triesifenidile, Tremin, Benzhexol hydrochloride, Artane hydrochloride
货号 T7002Cas号 52-49-3 一键复制产品信息 纯度: 99.65%
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Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) 是一种抗毒蕈碱类的抗帕金森病药物，结合至M1毒蕈碱受体。

Trihexyphenidyl hydrochloride

一键复制产品信息
Rating icon 很棒

纯度: 99.65%

货号 T7002Cas号 52-49-3

别名 盐酸苯海索, Triesifenidile, Tremin, Benzhexol hydrochloride, Artane hydrochloride

Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) 是一种抗毒蕈碱类的抗帕金森病药物，结合至M1毒蕈碱受体。

Trihexyphenidyl hydrochloride
其他形式的 “Trihexyphenidyl hydrochloride”:
DL-trihexyphenidyl hydrochlorideT132858947-95-8
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规格价格库存数量
100 mg
¥ 220
现货
500 mg
¥ 418
现货
1 mL x 10 mM (in DMSO)
¥ 242
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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
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纯度: 99.65%
颜色: 白色
性状: Solid
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资源下载:
COA HNMR LCMS产品操作手册

产品介绍

Trihexyphenidyl hydrochloride AI Summary
Trihexyphenidyl hydrochloride exhibits a wide range of biological activities across various assays. It shows potent binding affinity for human muscarinic receptors M1, M2, M3, M4, and M5, with IC50 values of 1.3 nM, 18.6 nM, 26.3 nM, 6.7 nM, and 10.3 nM, respectively, indicating its potential effects on muscarinic receptor-mediated pathways. The compound also demonstrates antiplasmodial activity against Plasmodium falciparum strains, with IC50 values from 2511.89 nM to 12589.25 nM. Additionally, it shows effectiveness in inhibiting proliferation of various Plasmodium falciparum lines (IC50 ranging from 3162.3 nM to 18526.0 nM). In antiviral assays, Trihexyphenidyl hydrochloride inhibits the entry of Lassa and Marburg viruses (potency ranging from 11220.2 nM to 23109.3 nM) and demonstrates inhibitory effects on SARS-CoV-2. It shows inhibition of SARS-CoV-2-induced cytotoxicity in Caco-2 cells and Vero E6 cells, with moderate activity levels. Specifically, it inhibits SARS-CoV-2 3CL-Pro protease by 6.361% at 20µM concentration. The compound also has significant inhibitory effects on OATP1B1 and OATP1B3 in CHO cells, with inhibition percentages of 83.05% and 73.95% at 10 µM, suggesting strong inhibition of sodium fluorescein uptake. In terms of antibacterial activity, Trihexyphenidyl hydrochloride exhibits moderate to strong inhibition against various bacterial strains, including Escherichia coli (7.07%), Klebsiella pneumoniae (14.55%), Pseudomonas aeruginosa (14.72%), Acinetobacter baumannii (37.84%), and Staphylococcus aureus MRSA (17.03%). It also shows some antifungal activity, with 4.22% inhibition of Candida albicans but minimal activity against Cryptococcus neoformans. Overall, Trihexyphenidyl hydrochloride demonstrates potential as a multi-functional agent with significant antimalarial, antiviral, and antibacterial properties, alongside notable activity on human muscarinic receptors..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is an antiparkinsonian agent of the antimuscarinic class.
别名盐酸苯海索, Triesifenidile, Tremin, Benzhexol hydrochloride, Artane hydrochloride
化学信息
分子量337.927
分子式C20H32ClNO
CAS No.52-49-3
SmilesCl.OC(CCN1CCCCC1)(C1CCCCC1)c1ccccc1
密度0.9801 g/cm3 (Estimated)
储存&溶解度
存储
溶解度信息
Ethanol: 23 mg/mL (68.06 mM), Sonication is recommended.
DMSO: 13 mg/mL (38.47 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
溶液配制表
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.9592 mL14.7961 mL29.5922 mL147.9610 mL
5 mM0.5918 mL2.9592 mL5.9184 mL29.5922 mL
10 mM0.2959 mL1.4796 mL2.9592 mL14.7961 mL
20 mM0.1480 mL0.7398 mL1.4796 mL7.3980 mL
Ethanol
1mg5mg10mg50mg
50 mM0.0592 mL0.2959 mL0.5918 mL2.9592 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

Trihexyphenidyl HydrochlorideTrihexyphenidylParkinson diseaseneuronalMuscarinic acetylcholine receptormAChRInhibitorinhibitdystoniaCholinesterase (ChE)Benzhexol HydrochlorideArtane Hydrochlorideanti-M1 muscarinic activityAChR58947-95-8
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