Fluorometholone Acetate

Name: Fluorometholone Acetate
Brand: TargetMol
SKU: T6503
Price: 127 CNY
Availability: InStock
Rating: 5 (10 reviews)

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产品编号 T6503Cas号 3801-06-7

别名 氟米龙醋酸酯, Oxylone acetate, NSC 47438, Flarex, Eflone

Fluorometholone Acetate (Oxylone acetate) 是合成的糖皮质激素皮质类固醇及皮质类固醇酯。它有效抑制碳酸酐酶 (CA) 对 hCA-I(IC50:2.18 μM)和 hCA-II(IC50:17.5 μM)。它具有抗炎活性，可用于研究外部眼部炎症。

还可以

纯度: 99.76%

产品编号 T6503 别名 氟米龙醋酸酯, Oxylone acetate, NSC 47438, Flarex, EfloneCas号 3801-06-7

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Fluorometholone Acetate 相关产品

产品介绍

生物活性

产品描述	Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
靶点活性	CA I (human):1.044 μM (Ki), CA II (human):17.5 μM (IC50), CA II (human):9.98 μM (Ki), CA I (human):2.18 μM (IC50)
体外活性	Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. [1]
体内活性	Hourly topical administration of the drug suspension produces an average reduction of 46.8% in the polymorphonuclear leukocytes invading the corneal stroma. In the cornea, fluorometholone acetate appears to have a greater efficacy, as compared to fluorometholone alcohol, for reducing the number of leukocytes invading that tissue following an inflammatory stimulus. Animal toxicity studies of fluorometholone, including acute intraperitoneal LD50s in mice and rats, subacute oral toxicity in rats and dogs, and subacute topical ocular toxicity in rabbits have demonstrated the safety of this drug for human use. [2]
别名	氟米龙醋酸酯, Oxylone acetate, NSC 47438, Flarex, Eflone

化学信息

分子量	418.5
分子式	C₂₄H₃₁FO₅
CAS No.	3801-06-7
Smiles	[H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C
密度	1.24 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 84 mg/mL (200.72 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

DMSO