AMXI-5001 hydrochloride is an orally active and potent inhibitor of parp1/2 and microtubule polymerization with significantly lower IC50 values than existing clinical PARP1/2 inhibitors. mxi-5001 hydrochloride exhibits selective antitumor cytotoxicity against a wide range of human cancer cells and is capable of inducing established tumors, including complete regression of larger tumors. including complete regression of larger tumors.