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Pinosylvin

Name: Pinosylvin
Brand: TargetMol
SKU: T3843
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.91%

货号 T3843Cas号 22139-77-1

别名 银松素, 5-Styrylresorcinol, 3,5-stilbenediol

Pinosylvin (5-Styrylresorcinol) 是从Pinus spp 的心材中分离出来的一种白藜芦醇类似物，可诱导白血病细胞凋亡和自噬。它是一种感染前的类苯乙烯类毒素，具有抗菌活性。

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Pinosylvin

一键复制产品信息

很棒

纯度: 99.91%

货号 T3843 别名 银松素, 5-Styrylresorcinol, 3,5-stilbenediolCas号 22139-77-1

规格	价格	库存
1 mg	¥ 108	现货
2 mg	¥ 139	现货
5 mg	¥ 218	现货
10 mg	¥ 313	现货
25 mg	¥ 515	现货
50 mg	¥ 758	现货
100 mg	¥ 1,120	现货
200 mg	¥ 1,660	现货
1 mL x 10 mM (in DMSO)	¥ 263	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.89%

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COA HNMR LCMS 产品操作手册

产品介绍

Pinosylvin AI Summary

Pinosylvin inhibits the protein-tyrosine kinase p56lck in vitro with an IC50 value of 193,000 nM using angiotensin I and [gamma-32P]-ATP. It also inhibits PGE-2 production in LPS-stimulated RAW264.7 cells with an IC50 value of 10,600 nM, and demonstrates significant anti-inflammatory effects in mouse J774 cells by reducing LPS-induced nitric oxide production, IL6 expression, and MCP1 expression, with IC50 values of 16,600 nM, 32,100 nM, and 38,700 nM, respectively. In addition, it shows ABTS and DPPH radical scavenging activities, displaying a trolox equivalent antioxidant capacity of 2.04 and a DPPH absorbance ratio of 0.52 relative to L-cysteine at 20 μM. The compound also exhibits antimicrobial activity against methicillin-resistant Staphylococcus aureus with MIC values of 125 μg/mL against S. aureus strains 5 and COL. It induces apoptosis in human HL60 cells, with 36.95% cell accumulation at the sub-G1 phase after 48 hours at 200 μM. Furthermore, Pinosylvin inhibits leukotriene formation in activated human neutrophils with an IC50 of 22,700 nM and demonstrates cytotoxicity against mouse Hepa 1c1c7 cells with a cell viability of 61% at 12.5 μM after 24 hours. It possesses various antioxidant activities, inhibiting AAPH-induced peroxidation and Cu2+-induced human LDL peroxidation, and delaying lipid oxidation based on the Rancimat method. The compound shows potent modulation of TRPV1 and TRPA1 receptors, serving as both an inhibitor and agonist with respective IC50 and efficacy values. Additionally, it inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells, with respective inhibition percentages of 114.57% and 133.48% at 10 μM. Pinosylvin is characterized by a log P value of 2.25, indicating moderate lipophilicity which may influence its bioavailability and efficacy..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.
别名	银松素, 5-Styrylresorcinol, 3,5-stilbenediol

化学信息

分子量	212.24
分子式	C₁₄H₁₂O₂
CAS No.	22139-77-1
Smiles	Oc1cc(O)cc(\C=C\c2ccccc2)c1
密度	1.252g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 122.5 mg/mL (577.18 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.42 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7116 mL	23.5582 mL	47.1165 mL	235.5824 mL
5 mM	0.9423 mL	4.7116 mL	9.4233 mL	47.1165 mL
10 mM	0.4712 mL	2.3558 mL	4.7116 mL	23.5582 mL
20 mM	0.2356 mL	1.1779 mL	2.3558 mL	11.7791 mL
50 mM	0.0942 mL	0.4712 mL	0.9423 mL	4.7116 mL
100 mM	0.0471 mL	0.2356 mL	0.4712 mL	2.3558 mL