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DL-Menthol

Name: DL-Menthol
Brand: TargetMol
SKU: T2979
Price: 147 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.74%

货号 T2979Cas号 89-78-1

别名 薄荷醇, Hexahydrothymol, DL-薄荷醇, 15356-70-4, (±)-Menthol

DL-Menthol ((±)-Menthol) 是单萜醇 (–)-薄荷醇和 (+)-薄荷醇的外消旋混合物，已在大麻中发现。它与 GABAA 受体的激活有关。

DL-Menthol

一键复制产品信息

很棒

纯度: 99.74%

货号 T2979 别名 薄荷醇, Hexahydrothymol, DL-薄荷醇, 15356-70-4, (±)-MentholCas号 89-78-1

DL-Menthol ((±)-Menthol) 是单萜醇 (–)-薄荷醇和 (+)-薄荷醇的外消旋混合物，已在大麻中发现。它与 GABAA 受体的激活有关。

规格	价格	库存
500 mg	¥ 147	现货
1 g	¥ 198	现货
5 g	¥ 413	现货
1 mL x 10 mM (in DMSO)	¥ 162	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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COA HNMR GC 产品操作手册

产品介绍

生物活性

产品描述

DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, antibacterial, and anticancer properties, as well as inhibits cholinesterase.2 (+)-Menthol inhibits the growth of F. verticillioides (MIC: 1.5 mM) but, unlike (–)-menthol, does not exhibit analgesic, antibacterial, anticancer, or cholinesterase inhibitory activities.

别名

薄荷醇, Hexahydrothymol, DL-薄荷醇, 15356-70-4, (±)-Menthol

化学信息

分子量	156.27
分子式	C₁₀H₂₀O
CAS No.	89-78-1
Smiles	[C@H](C)(C)[C@H]1[C@H](O)C[C@H](C)CC1
密度	0.89
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: Soluble

H2O: Insoluble

DMSO: 245 mg/mL (1567.8 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.3992 mL	31.9959 mL	63.9918 mL	319.9590 mL
5 mM	1.2798 mL	6.3992 mL	12.7984 mL	63.9918 mL
10 mM	0.6399 mL	3.1996 mL	6.3992 mL	31.9959 mL
20 mM	0.3200 mL	1.5998 mL	3.1996 mL	15.9980 mL
50 mM	0.1280 mL	0.6399 mL	1.2798 mL	6.3992 mL
100 mM	0.0640 mL	0.3200 mL	0.6399 mL	3.1996 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

DL-Menthol is a multifaceted molecule demonstrating various bioactivities. It functions as an inhibitor of COX2, showing an inhibition rate of less than 30.0% at 100 μM and 60.0% at 0.1 μg/mL. The compound is active in the expressed human recombinant enzymes UGT1A4 and UGT2A1, with activities recorded at 41.0 pm/min/mg and 32.0 pm/min/mg, respectively. It also exhibits lytic activity against Monographella nivalis var. nivalis MAFF 305031, causing 45.7% hyphal lysis at 0.2 mg/ml after 48 hours. Additionally, DL-Menthol acts as an agonist at TRPM8 in differentiated rat/mouse F11 cells and in human TRPM8 receptors, with EC50 values of 23400.0 nM and 10100.0 nM, respectively. It also activates human TRPA1 receptors with an EC50 of 96000.0 nM. Its agonist activity extends to the N-terminal rat ST3 receptor-fused human TAS2R7 in HEK293T cells, indicating calcium signaling in a concentration-dependent manner up to 2.60 mM. Further bioactivities include inhibition of human Apurinic/apyrimidinic Endonuclease 1 (APE1) at 50.1 nM, and Cav1.2 calcium current in rabbit ventricular myocytes with an IC50 of 74600.0 nM. It acts as an antagonist on human OR5K1 in HEK293 cells, inhibiting the response to 2,6-dimethylpyrazine by at least 50.0% at 100 μM. Despite these activities, DL-Menthol has limited effect on the SARS-CoV-2 3CL-Pro protease and SARS-CoV-2 induced cytotoxicity of VERO-6 cells. The compound shows minimal antiviral activity with an 11.1% inhibition of the 3CL-Pro protease at 20 μM and a -0.18% inhibition of cytotoxicity at 10 μM. Activity assays on human HDAC6 report low inhibition rates of 2.89% and -3.28% depending on the substrate used. Lastly, although tested extensively, the compound displayed no significant activity in assays with AC50 values exceeding 30,000.0 nM..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl