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Ranitidine

Name: Ranitidine
Brand: TargetMol
SKU: T3610
Price: 266 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.52%

货号 T3610Cas号 66357-35-5

别名 雷尼替丁, Ranitidin, HSDB 3925

Ranitidine (HSDB 3925) 是一种选择性的，具有口服活性的组胺 H2 受体拮抗剂，IC50为 3.3 μM。它还一种是CYP2C19和CYP2C9的弱抑制剂，可抑制胃液分泌。

Ranitidine

一键复制产品信息

很棒

纯度: 99.52%

货号 T3610 别名 雷尼替丁, Ranitidin, HSDB 3925Cas号 66357-35-5

Ranitidine (HSDB 3925) 是一种选择性的，具有口服活性的组胺 H2 受体拮抗剂，IC50为 3.3 μM。它还一种是CYP2C19和CYP2C9的弱抑制剂，可抑制胃液分泌。

规格	价格	库存
5 mg	¥ 266	现货
10 mg	¥ 379	现货
25 mg	¥ 659	现货
50 mg	¥ 968	现货
100 mg	¥ 1,430	现货
200 mg	¥ 2,130	现货
500 mg	¥ 3,450	现货
1 mL x 10 mM (in DMSO)	¥ 323	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.52%

颜色: 红色

性状: Viscous

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Ranitidine AI Summary

Ranitidine exhibits significant histamine H2 and H3 receptor antagonistic activities with KB values of 6.3E-8 and 0.0000012, respectively, indicating its high potency in inhibiting these receptors. The compound demonstrates a binding affinity to the histamine H2 receptor with a pKB value of 7.2 and shows an inhibitory effect on histamine-induced responses in animal models, including a 72% inhibition of gastric acid secretion in rats and a 44% inhibition of chronotropic response in guinea pig right atrium. It also inhibits acetylcholinesterase with an IC50 of 650 nM and enhances gastrointestinal motility with an EC30 of 1.8 µM in guinea pig ileum. Pharmacokinetic studies reveal that Ranitidine has a volume of distribution (Vdss) of 1.3 L.kg-1, a high fraction unbound in plasma (Fu = 0.85), and a pKa of 8.47, suggesting good distribution within the body. The compound is moderately absorbed in the human GI tract (50% absorption) and displays low intrinsic clearance in human hepatocytes, suggesting metabolic stability. Despite its pronounced pharmacological activities, Ranitidine exhibits low permeability across biological membranes, with permeability values ranging from 0.2 to 5.6 x 10^-6 cm/s in various assays, and is characterized by low lipophilicity (logD7.4 = -0.29). It also possesses hepatic clearance with a logCL value of 0.4624 and weak inhibition activity against several transporters and enzymes, implying limited potential for significant metabolic interactions. Additionally, the compound has shown some degree of liver toxicity, reflected in changes in liver enzyme levels. Overall, Ranitidine presents as a potent histamine receptor antagonist with sizable effects on gastrointestinal and enzymatic activities, coupled with pharmacokinetic properties that favour distribution and stability but are limited by low permeability and moderate-to-high potential for hepatotoxicity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ranitidine (HSDB 3925) is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
靶点活性	H2 receptor:3.3 μM (IC50)
别名	雷尼替丁, Ranitidin, HSDB 3925

化学信息

分子量	314.40
分子式	C₁₃H₂₂N₄O₃S
CAS No.	66357-35-5
Smiles	C(N(C)C)C=1OC(CSCCNC(=CN(=O)=O)NC)=CC1
密度	1.184 g/cm3

储存&溶解度

存储

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (795.17 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (7.95 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1807 mL	15.9033 mL	31.8066 mL	159.0331 mL
5 mM	0.6361 mL	3.1807 mL	6.3613 mL	31.8066 mL
10 mM	0.3181 mL	1.5903 mL	3.1807 mL	15.9033 mL
20 mM	0.1590 mL	0.7952 mL	1.5903 mL	7.9517 mL
50 mM	0.0636 mL	0.3181 mL	0.6361 mL	3.1807 mL
100 mM	0.0318 mL	0.1590 mL	0.3181 mL	1.5903 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

secretion Ranitidine orally Inhibitor inhibit HSDB-3925 HSDB3925 HistamineReceptor Histamine Receptor H2-receptor H2 receptor Gastric Cytochrome P450 CYPs CYP2C9 CYP2C19 Bacterial

Ranitidine

Ranitidine

Ranitidine 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

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