购物车
您的购物车当前为空
TCS JNK 5a
一键复制产品信息
很棒纯度: 99.51%
货号 T2234Cas号 312917-14-9
别名 SC-202671, SC202671, SC 202671, N-(3-氰基-4,5,6,7-四氢苯并[b]噻吩-2-基)-1-萘甲酰胺, N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide, JNK Inhibitor IX
TCS JNK 5a (SC202671) 是一种 JNK2和 JNK3的有效抑制剂，pIC50分别为 6.5和 6.7。
为众多的药物研发团队赋能，
让新药发现更简单！
TCS JNK 5a
一键复制产品信息 很棒纯度: 99.51%
货号 T2234 别名 SC-202671, SC202671, SC 202671, N-(3-氰基-4,5,6,7-四氢苯并[b]噻吩-2-基)-1-萘甲酰胺, N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide, JNK Inhibitor IXCas号 312917-14-9
TCS JNK 5a (SC202671) 是一种 JNK2和 JNK3的有效抑制剂，pIC50分别为 6.5和 6.7。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 145 | 现货 | |
| 5 mg | ¥ 372 | 现货 | |
| 10 mg | ¥ 578 | 现货 | |
| 25 mg | ¥ 1,050 | 现货 | |
| 50 mg | ¥ 1,790 | 现货 | |
| 100 mg | ¥ 2,770 | 现货 | |
| 500 mg | ¥ 6,350 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 397 | 现货 |
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
产品介绍
TCS JNK 5a AI Summary
TCS JNK 5a inhibits human truncated JNK3 with an IC50 value of 199.53 nM and human JNK2alpha2 with an IC50 value of 316.23 nM. It shows negligible inhibitory activity against a range of kinases including CDK2, p38alpha, Alk5, cFms, EGFR, ErbB2, GSK3-beta, PLK1, Src, Tie2, and VegFr2, with IC50 values exceeding 10,000 nM for these targets.
In addition to its kinase inhibition profile, TCS JNK 5a demonstrates inhibitory activity against various viruses including Lassa Virus and Marburg Virus, and inhibits the proliferation of Plasmodium falciparum strains (3D7, DD2, HB3) with potency values ranging from 10.6 nM to 11875.4 nM.
Further, this compound shows complex bioactivity, with minor inhibition percentages at 1 µM concentration on targets such as IKK-alpha (-1.0% to 2.0%), IKK-beta (-2.0% to 0.0%), and IKK-epsilon (-2.0% to -3.0%). It significantly inhibits Mer Kinase (78.0% at 10 µM), and presents varying inhibition on TBK1 (-3.0% to -4.0% at 1 µM).
TCS JNK 5a inhibits Firefly Luciferase with an AC50 value of 18337.4 nM as indicated by GSK_PKIS assays and shows moderate inhibition of the SARS-CoV-2 3CL-Pro protease (15.68% at 20 µM) using FRET methodology. Additionally, it provides slight antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in VERO-6 cells (1.37% inhibition at 10 µM over 48 hours exposure to 0.01 MOI).
Finally, in a primary screen using the NF54 nanoGlo assay, TCS JNK 5a had a Z score of 3.59 and an inhibition of -21.0% at a 2 µM concentration over 72 hours..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5). |
| 靶点活性 | JNK3:6.7(pIC50), JNK2:6.5(pIC50) |
| 体内活性 | 在人皮肤成纤维细胞中,JNK inhibitor IX能够介导c-Jun氨基末端激酶抑制丝氨酸残基上c-ABL的完全去磷酸化,从而显著降低caspase-3活性。 |
| 别名 | SC-202671, SC202671, SC 202671, N-(3-氰基-4,5,6,7-四氢苯并[b]噻吩-2-基)-1-萘甲酰胺, N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide, JNK Inhibitor IX |
| 分子量 | 332.42 |
| 分子式 | C20H16N2OS |
| CAS No. | 312917-14-9 |
| Smiles | O=C(NC1=C(C#N)C2=C(CCCC2)S1)C1=C2C=CC=CC2=CC=C1 |
| 密度 | 1.32 g/cm3 at 20℃ |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| 溶解度信息 | DMSO: 3.33 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
预览
Related Tags: buy TCS JNK 5a | purchase TCS JNK 5a | TCS JNK 5a cost | order TCS JNK 5a | TCS JNK 5a chemical structure | TCS JNK 5a in vivo | TCS JNK 5a formula | TCS JNK 5a molecular weight
嗨！有任何问题？点我咨询
版权所有©2015-2026 TargetMol Chemicals Inc.保留所有权利.
沪ICP备20019793号-4 | 沪公网安备 31010602006700号
| 沪(静)应急管危经许[2024]203441