规格

价格

库存

数量

1 mg

¥ 1,590

现货

5 mg

¥ 3,270

现货

10 mg

¥ 4,680

现货

25 mg

¥ 7,190

现货

50 mg

¥ 9,680

现货

100 mg

¥ 12,800

现货

生物活性

产品描述

PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC 50 of 36 μM. PIP-199 can be used for the study of the mechanisms underlying DNA crosslink repair and could serve as sensitizing chemoresistant tumors [1].

体外活性

MM2 is a peptide which is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM) [1]. Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies [1]. Proper execution of the FA pathway requires interaction between the FANCM and the RMI complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents [1].

化学信息

分子量	456.54
分子式	C₂₇H₂₈N₄O₃
CAS No.	622795-76-0
Smiles	CCOC(=O)N1CCN(CC1)C(c1c(-c2ccccc2)n(O)c2ccccc12)c1ccccn1
密度	no data available
颜色	Yellow
物理性状	Solid