购物车

您的购物车当前为空

Pimonidazole

Name: Pimonidazole
Brand: TargetMol
SKU: T16537
Price: 257 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 哌莫硝唑

货号 T16537Cas号 70132-50-2 一键复制产品信息纯度: 99.99%

很棒

Pimonidazole 是缺氧标记物，能够与大分子的共价结合或被还原形成还原性代谢物后在缺氧细胞中积累，可用于定性和定量评估肿瘤缺氧。它可用于瘤内缺氧和细胞增殖的补充性研究。

Pimonidazole

一键复制产品信息

很棒

纯度: 99.99%

货号 T16537Cas号 70132-50-2

别名 哌莫硝唑

规格	价格	库存
5 mg	¥ 257	现货
10 mg	¥ 387	现货
25 mg	¥ 845	现货
50 mg	¥ 1,630	现货
100 mg	¥ 2,890	现货
200 mg	¥ 4,220	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.99%

颜色: 黄色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Pimonidazole AI Summary

Pimonidazole exhibits multifaceted bioactivity, showing potential in both oncology and antiviral domains. It demonstrates aerobic growth inhibition in Chinese hamster cell line AA8 with an IC50 of 3030 µM and displays hypersensitivity in several cell lines such as UV4, EMT6, and FME. In addition, the compound is effective in reducing cell survival under hypoxic conditions as measured by the clonogenic assay, and it shows differential sensitivity under aerobic and hypoxic conditions with various CT10 values. For its physicochemical properties, Pimonidazole has a pKa of 8.8 in EMT6 mouse mammary tumor cells under different oxygen conditions and a partition coefficient of 0.4 in n-octanol at pH 7.4. The compound also exhibits broad-spectrum growth inhibitory effects against several human tumor cell lines, including those of breast, renal, non-small cell lung, leukemia, central nervous system, colon, melanoma, ovarian, and prostate origins, with a consistent GI50 of 100 µM. In the antiviral arena, Pimonidazole shows activity against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 cells with an inhibition rate of -10.89% at 10 µM after 48 hours. It also acts as an inhibitor of the SARS-CoV-2 3CL-Pro protease with inhibition rates of 41.54% at 20 µM, although its efficacy varies across different assays. Finally, Pimonidazole has displayed inhibitory activity against human HDAC6 enzyme, with an inhibition rate of 17.08% using a commercial peptide substrate and 9.72% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. It can be used for qualitative and quantitative assessment of tumor hypoxia. Pimonidazole is a novel hypoxia marker for the complementary study of tumor hypoxia and cell proliferation in tumors.
别名	哌莫硝唑

化学信息

分子量	254.29
分子式	C₁₁H₁₈N₄O₃
CAS No.	70132-50-2
Smiles	OC(CN1CCCCC1)Cn1ccnc1[N+]([O-])=O
密度	1.39g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 60 mg/mL (235.95 mM), Sonication is recommended.

H2O: 1 mg/mL (3.93 mM), Sonication is recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9325 mL	19.6626 mL	39.3252 mL	196.6259 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.7865 mL	3.9325 mL	7.8650 mL	39.3252 mL
10 mM	0.3933 mL	1.9663 mL	3.9325 mL	19.6626 mL
20 mM	0.1966 mL	0.9831 mL	1.9663 mL	9.8313 mL
50 mM	0.0787 mL	0.3933 mL	0.7865 mL	3.9325 mL
100 mM	0.0393 mL	0.1966 mL	0.3933 mL	1.9663 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。