规格

价格

库存

数量

50 mg

¥ 115

现货

100 mg

¥ 153

现货

500 mg

¥ 328

现货

1 g

¥ 418

现货

5 g

¥ 993

现货

10 g

¥ 1,460

现货

1 mL x 10 mM (in DMSO)

¥ 363

现货

生物活性

产品描述	Losartan potassium (DuP-753 potassium) , an Angiotensin II Receptor Blocker, selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor.
靶点活性 (IC₅₀)	AT1 receptor:20 nM
体外活性	Losartan 与血管紧张素II竞争性地结合AT1受体。其抑制血管紧张素II结合50%所需浓度（IC₅₀）为20 nM^[1]。Losartan （40μM）影响ISC，但可阻止ANGII对ISC的作用^[2]。Losartan 显著降低血管紧张素II介导的子宫内膜癌细胞增殖。Losartan 与抗miR-155联合使用，相比单药治疗具有更显著的抑制增殖效果^[3]。
细胞实验	An MTT assay is used to measure cell proliferation and viability. For the assay, 5000 cells in 200?μL media per well are seeded in a 96 well plate. After overnight incubation to allow for cell attachment, the medium is removed by suction. MTT at 1?mg/mL concentration in serum-free medium is added and then incubated for 4?h at 37°C. After removal of MTT solution, 100?μL of DMSO is added to dissolve formazan crystals. Absorbance at 570?nm and at 600?nm as a reference is then measured using a microplate reader. The difference in absorbance is thus relative to the extent of cell survival.
别名	洛沙坦钾, 氯沙坦钾, MK 954, DuP-753 potassium, DuP 753

化学信息

分子量	421.903
分子式	C₂₂H₂₂ClN₆O
CAS No.	124750-99-8
Smiles	CCCCC1=NC(Cl)=C(C[O-])N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NN=NN1
密度	0.986?g/mL?at 25?°C(lit.)

储存&溶解度

存储

Store under nitrogen,Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: 46.10 mg/mL (109.27 mM), Sonication is recommended.

DMSO: 250.00 mg/mL (592.55 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Saline: 10.00 mg/mL (23.70 mM), Solution.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3702 mL	11.8511 mL	23.7021 mL	118.5107 mL
5 mM	0.4740 mL	2.3702 mL	4.7404 mL	23.7021 mL
10 mM	0.2370 mL	1.1851 mL	2.3702 mL	11.8511 mL
20 mM	0.1185 mL	0.5926 mL	1.1851 mL	5.9255 mL
50 mM	0.0474 mL	0.2370 mL	0.4740 mL	2.3702 mL
100 mM	0.0237 mL	0.1185 mL	0.2370 mL	1.1851 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Losartan potassium

Losartan potassium

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

Losartan potassium

Losartan potassium