SIRT5 inhibitor 7 (compound 58), a substrate-competitive and selective SIRT5 inhibitor with IC 50 = 310 nM, significantly attenuated renal dysfunction and pathological damage in lipopolysaccharide (LPS)- and cecum ligation/perforation (CLP)-induced septic AKI mice, and modulated proteinsuccinimidylation and proinflammatory cytokine release and pro-inflammatory cytokine release in the kidneys of acute kidney injury (AKI) mice.

SIRT5:310 nM

SIRT5 inhibitor 7 是一种高效的 SIRT5 抑制剂，IC₅₀ 为 310 nM，为底物竞争性、选择性抑制剂。体外实验中，SIRT5 inhibitor 7 有效抑制 SIRT5 酶活性，并调控蛋白琥珀酰化水平[1]。

在LPS和盲肠结扎穿孔（CLP）诱导的脓毒性急性肾损伤（AKI）小鼠模型中，SIRT5 inhibitor 7 显著改善肾功能、减轻组织损伤，并抑制肾组织中促炎因子的释放[1]。