规格

价格

库存

数量

50 mg

¥ 148

现货

100 mg

¥ 198

现货

500 mg

¥ 413

现货

1 g

¥ 588

现货

2 g

¥ 867

现货

5 g

¥ 1,470

现货

1 mL x 10 mM (in DMSO)

¥ 127

现货

生物活性

产品描述	Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19 nM at pH 6.5.
靶点活性	H+, K+-ATPase:19 nM
体外活性	The inhibitory activity of Vonoprazan Fumurate was unaffected by ambient pH. The inhibition by Vonoprazan Fumurate was reversible and achieved in a K(+)-competitive manner, quite different from that by lansoprazole. Vonoprazan Fumurate exhibits porcine gastric H+ ,K+-ATPase activity in a concentration-dependent manner[4].
体内活性	Vonoprazan Fumurate, at a dose of 4 mg/kg (as the free base) orally, completely inhibited basal and 2-deoxy-d-glucose-stimulated gastric acid secretion in rats, and its effect on both was stronger than that of lansoprazole. Vonoprazan Fumurate increased the pH of gastric perfusate to a higher value than did lansoprazole or SCH28080, and the effect of Vonoprazan Fumurate was sustained longer than that of lansoprazole or SCH28080[4].
别名	富马酸沃诺拉赞, Vonoprazan Fumurate, TAK-438, TAK438, TAK 438, 1260141-27-2

化学信息

分子量	461.46
分子式	C₂₁H₂₀FN₃O₆S
CAS No.	881681-01-2
Smiles	OC(=O)\C=C\C(O)=O.CNCc1cc(-c2ccccc2F)n(c1)S(=O)(=O)c1cccnc1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

Ethanol: 45.45 mg/mL (98.49 mM), Sonication is recommended.

DMSO: 71.43 mg/mL (154.79 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Saline: 7.14 mg/mL (15.47 mM), Solution.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.17 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1670 mL	10.8352 mL	21.6704 mL	108.3518 mL
5 mM	0.4334 mL	2.1670 mL	4.3341 mL	21.6704 mL
10 mM	0.2167 mL	1.0835 mL	2.1670 mL	10.8352 mL
20 mM	0.1084 mL	0.5418 mL	1.0835 mL	5.4176 mL
50 mM	0.0433 mL	0.2167 mL	0.4334 mL	2.1670 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0217 mL	0.1084 mL	0.2167 mL	1.0835 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Vonoprazan Fumarate

Vonoprazan Fumarate

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

Vonoprazan Fumarate

Vonoprazan Fumarate