TAT-P4-(DATC5)2 is a potent peptide inhibitor targeting the PDZ domain of protein interacting with C kinase-1 (PICK1), exhibiting a high affinity with a dissociation constant (K_i) of 1.7 nM. This compound has demonstrated the capacity to mitigate addiction behaviors in rat models [1].

TAT-P4-(DATC5)2 (0.99 μg/kg，9.9 μg/kg；静脉内输注) 能够剂量依赖地减弱大鼠成瘾性物质寻求行为的复发，且不会导致操作性学习障碍或抑制其运动活动[1]。