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GATA4-NKX2-5-IN-1

Name: GATA4-NKX2-5-IN-1
Brand: TargetMol
SKU: T11368
Price: 333 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T11368Cas号 544681-96-1 一键复制产品信息纯度: 99.65%

很棒

GATA4-NKX2-5-IN-1 剂量依赖性地抑制 GATA4–NKX2-5转录协同作用(IC50:3 μM)，但不影响参与调节 GATA4 磷酸化的蛋白激酶的活性。它能够调节肥大激动剂诱导的心脏基因表达。

GATA4-NKX2-5-IN-1

一键复制产品信息

很棒

纯度: 99.65%

货号 T11368Cas号 544681-96-1

规格	价格	库存
1 mg	¥ 333	现货
5 mg	¥ 833	现货
10 mg	¥ 1,130	现货
25 mg	¥ 1,780	现货
50 mg	¥ 2,410	现货
100 mg	¥ 3,190	现货
1 mL x 10 mM (in DMSO)	¥ 648	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.65%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

GATA4-NKX2-5-IN-1 AI Summary

GATA4-NKX2-5-IN-1 inhibits the binding to the human growth hormone secretagogue receptor with an IC50 value of 8200.0 nM and the ghrelin-induced increase of intracellular [Ca2+] in CHO K cells with an IC50 value of 7600.0 nM. It acts as an antagonist at multiple receptors, including human GHS-R, GPR109A, PTH2 receptor, and CB2 receptor, showing inhibition percentages between 58.5% and 91.8% at a 10 µM concentration. It exhibits inhibitory effects on mouse GATA4/NKX2-5 transcriptional synergy with an IC50 of 3000.0 nM in COS-1 cells, and affects the interaction of GATA4/NKX2-5 in neonatal rat ventricular cardiomyocytes, leading to decreased mRNA levels of BNP and ANP, with inhibition percentages ranging from 32.0% to 81.0% at 10 µM concentration. GATA4-NKX2-5-IN-1 also inhibits VEGFR2 and EGFR at 30 µM with inhibition percentages of 64.0% and 54.0%, respectively, and the binding of GATA4 to [32P]-double stranded oligonucleotide with an inhibition percentage of 29.0% at 50 µM concentration. Furthermore, it influences the transcriptional activity of mouse NKX2-5 and GATA4 individually, showing activities of 49.0% and 62.0%, respectively, and induces cytotoxic effects, reducing cell viability by more than 10% at certain concentrations..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression.GATA4-NKX2-5-IN-1 dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM.
靶点活性	GATA4–NKX2-5:3 μM

化学信息

分子量	349.43
分子式	C₂₁H₂₃N₃O₂
CAS No.	544681-96-1
Smiles	C(NC1=CC=C(N(CC)CC)C=C1)(=O)C=2C(=NOC2C)C3=CC=CC=C3
密度	1.176 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 65 mg/mL (186.02 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2.5 mg/mL (7.15 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8618 mL	14.3090 mL	28.6180 mL	143.0902 mL
5 mM	0.5724 mL	2.8618 mL	5.7236 mL	28.6180 mL
10 mM	0.2862 mL	1.4309 mL	2.8618 mL	14.3090 mL
20 mM	0.1431 mL	0.7155 mL	1.4309 mL	7.1545 mL
50 mM	0.0572 mL	0.2862 mL	0.5724 mL	2.8618 mL
100 mM	0.0286 mL	0.1431 mL	0.2862 mL	1.4309 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。