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lysosomal autophagy

Pre-lysosomes form de novo in the cytoplasm from a cup-shaped membrane called a phagophore. The edges of the phagophore expand while becoming spherical until they seal, enclosing the engulfed pieces of cytoplasm with whatever might lie inside, and giving rise to a double-membrane vesicle. Farquhar observed these closed vesicles, which are known as autophagosomes. Autophagosomes take up damaged molecules or organelles and carry this cargo to the lysosomes. When de Duve observed autophagosomes, he realized that cells could degrade their own components and named the process "autophagy"

Cat. No.	Product Name	CAS No.	Purity
T3437	Lys05 化合物Lys05	1391426-24-6	98%
T3437	Lys05 是一种有效的水溶性溶酶体自噬抑制剂，具有抗肿瘤活性。在 MTT 试验中，对1205Lu、c8161、LN229 和 HT-29细胞系的IC50值分别为3.6、3.8、6 和7.9 μM。
T1885	Siramesine hydrochloride 西拉美新盐酸盐	224177-60-0	98%
T1885	Siramesine hydrochloride 是一种选择性 sigma-2 受体激动剂，可引发 Y 细胞的细胞死亡并在体内表现出有效的抗癌活性。Siramesine 对 sigma-2 受体具有亚纳摩尔亲和力，并且对 sigma-2 受体的选择性是 sigma-1 受体的 140 倍。