规格

价格

库存

数量

1 mg

¥ 238

现货

5 mg

¥ 552

现货

10 mg

¥ 938

现货

25 mg

¥ 1,880

现货

50 mg

¥ 2,950

现货

100 mg

¥ 4,330

现货

200 mg

¥ 5,920

现货

1 mL x 10 mM (in DMSO)

¥ 597

现货

生物活性

产品描述	VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.
靶点活性	mGluR1 (rat):356 nM (EC50), mGluR1(human):390 nM (EC50), mGlu4 (human):>10 μM (EC50)
体外活性	VU0483605 shows excellent mGlu1 PAM activity at both human and rat (pEC50 = 6.45 ± 0.11, 113 ± 5% Glu Max) and no activity as an mGlu4 PAM (EC50 >10 μM)[1].

化学信息

分子量	446.67
分子式	C₂₀H₁₀Cl₃N₃O₃
CAS No.	1623101-11-0
Smiles	Clc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl
密度	1.625 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 95 mg/mL (212.68 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.39 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO