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FDA 上市药物库

FDA 上市药物库

产品编号 L4200 FDA-Approved Drug Library
  库化合物信息   Excel SDF

FDA 上市药物库中的所有化合物都具有良好的生物活性、明确的靶点信息,较好的安全性和生物利用度,这些特性可显著加速药物开发和优化,是进行小分子细胞诱导分化和药物重定位理想的工具。详尽的数据资料可以帮助科学家快速完成药物筛选或细胞诱导机制的判断,并为深入揭示其机制机理创造条件。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
TargetMol Compound Library
规格
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
如果上述化合物库无法满足您的需求,您可发送邮件至tech@targetmol.com咨询我们的技术专员,为您量身定制专属化合物库!
咨询化合物库
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产品描述

  • 1729个FDA批准药物的独特集合,可用于高通量筛选和高内涵筛选;
  • 全部得到FDA批准,提供FDA批准编号,用于药物重定位、新的药物靶点筛选的有效工具;
  • 经过了严格的临床前研究和临床试验,生物活性和安全性得到保障;
  • 涵盖多个研究领域:肿瘤、心血管药物、抗炎、免疫、神经系统药物、呼吸系统药物等;
  • 结构多样,药效显著,可渗透细胞;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

化合物库定制

TargetMol的化合物可以高度定制! 了解更多

包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L4200)
点击图片重新获取验证码

TargetMol Library Books客户使用化合物库发表的文献

1. Nature Biotechnology. 2021, 39(11): 1444-1452. 2. ACS Central Science. 2023. 3. Nature Communications. 2023, 14(1): 2756.. 4. Nature Communications. 2023, 14(1): 1020.. 5. Blood. 2021, 137(11): 1478-1490. 6. Advanced Science. 2021: 2101957. 7. Protein & Cell. 2021: 1-19.. 8. Bone Research. 2023, 11(1): 54. 9. Journal of Experimental & Clinical Cancer Research. 2023, 42(1): 1-27..
10. Pharmacology & Therapeutics. (2021): 107930. 11. Microbial Biotechnology. 2022, 15(2): 482-498. 12. Journal of Translational Medicine. 2022, 20(1): 1-11.. 13. Cancer Research. 2020. 14. Neuropsychopharmacology. 2022: 1-9. 15. Theranostics. 2020, 10(13): 5749-5762. 16. PLoS Biology. 2021, 19(10): e3001425. 17. Journal of Medicinal Chemistry. 2023. 18. Immunology. 2023;1–10.. 19. Microbiology Spectrum. 2022: e00884-22. 20. Elife. 2021, 10: e65962. 21. Translational Research. 2022. 22. European Journal of Medicinal Chemistry. 2023: 116018.. 23. International Journal of Molecular Sciences. 2022, 23(19): 11250. 24. Fundamental Research. 2023. 25. Cell Death & Disease. 2020, 11(3): 1-12. 26. International Journal of Molecular Sciences. 2022, 23(7): 4050. 27. International Journal of Molecular Sciences. 2020. 28. Viruses. 2021 Jun 3;13(6):1061. 29. International Journal of Oncology. 2022, 60(6): 1-13. 30. Journal of Molecular Cell Biology. 2023: mjad056. 31. Journal of Virus Eradication. 2023: 100327.. 32. Frontiers in Immunology. 2020, 11. 33. Scientific Reports. 2022 Nov 2;12(1):18506. 34. Molecules. 2022, 27(15): 5000.. 35. Antimicrobial agents and chemotherapy. 2021, 65(4): e02577-20. 36. Antimicrobial Agents and Chemotherapy. 2020, 64(9). 37. CNS Oncology. 2020. 38. Viruses. 2023, 15(8): 1666.. 39. ACS Infectious Diseases. 2021 Aug 13;7(8):2337-2351. 40. Journal of virology. 2018, 92(20): e01018-18.. 41. Virologica Sinica. 2022. 42. Journal of Proteome Research. 2020. 43. Journal of Biological Chemistry. 2016 Apr;291(17): 9218-9232.. 44. Acta Pharmacologica Sinica, 2019, 40(12): 1568-1577. 45. Neoplasia. 2020, 22(4): 179-191. 46. Virology. 2022. 47. Molecular Informatics. 2022. 48. Journal of Biomolecular Structure and Dynamics. 2020: 1-16. 49. Journal of Clinical Medicine. 2020, 9(5): 1473. 50. RSC Advances. 2021, 11(4): 2158-2166. 51. Orthopaedic Surgery. 2023. 52. Interdisciplinary Sciences: Computational Life Sciences, 2020, 12: 368-376. 53. Hollis R L, Elliott R, Dawson J C, et al.High throughput screening identifies dasatinib as synergistic with trametinib in low grade serous ovarian carcinoma.Gynecologic Oncology.2024, 186: 42-52. 54. Dou X, Huo T, Liu Y, et al.Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation.European Journal of Medicinal Chemistry.2024: 116323. 55. bioRxiv. 2023: 2023.05. 24.542186.. 56. SSRN. 2023. 57. bioRxiv. 2021. 58. AIP Publishing LLC. 2021, 2370(1): 070005. 59. researchsquare. 2022. 60. Chemrxiv. 2020. 61. Cell Stem Cell. 2022 Apr 29(4) 545–558. 62. Science Bulletin. 2022. 63. Science Translational Medicine. 2022, 14(656): eabn3231. 64. Science Advances. 2023, 9(9): eade3760. 65. Nature. 2020, 582: 289-293. 66. Nature Communications. 2022, 13(1): 1-15.. 67. Nucleic Acids Research. 2021. 68. Nature Communications. 2023, 14(1): 7574. 69. Advanced Science. 2020, 7(16): 2000925. 70. Angewandte Chemie. 2021. 71. Acta Pharmaceutica Sinica B. 2022. 72. Protein & Cell. 2021, 12(11): 877-888. 73. Nature Communications. 2021, 12(1): 1-12. 74. Journal of Cell Biology. 2022, 221(5): e202112024. 75. Liu T, Yue X, Chen X, et al.Nilotinib in combination with sunitinib renders MCL-1 for degradation and activates autophagy that overcomes sunitinib resistance in renal cell carcinoma.Cellular Oncology.2024: 1-18. 76. Fang Z Y, Zhang Z Y, Zheng Y D, et al.Repurposing cinacalcet suppresses multidrug-resistant Staphylococcus aureus by disruption of cell membrane and inhibits biofilm by targeting IcaR.Journal of Antimicrobial Chemotherapy.2024: dkae051. 77. Cao Z, Hou Y, Zhao Z, et al.Reactivating Hippo by Drug Compounds to Suppress Gastric Cancer and Enhance Chemotherapy Sensitivity.Journal of Biological Chemistry.2024: 107311.
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化合物库组成

Antibacterial (256)
Autophagy (248)
Antibiotic (248)
Apoptosis (166)
Endogenous Metabolite (129)
Adrenergic Receptor (115)
5-HT Receptor (111)
AChR (82)
Histamine Receptor (75)
Dopamine Receptor (70)
HIV Protease (70)
COX (59)
Parasite (57)
Sodium Channel (57)
DNA/RNA Synthesis (54)
Antifungal (53)
Potassium Channel (48)
Glucocorticoid Receptor (43)
Calcium Channel (38)
Estrogen/progestogen Receptor (38)
P450 (34)
Topoisomerase (34)
Ferroptosis (30)
SARS-CoV (30)
RAAS (27)
Serotonin Transporter (27)
ribosome (26)
c-Kit (25)
VEGFR (25)
Dehydrogenase (24)
Mitophagy (24)
PDE (24)
GABA Receptor (23)
Microtubule Associated (23)
Antifection (22)
Reverse Transcriptase (22)
Nucleoside Antimetabolite/Analog (22)
Norepinephrine (21)
HSV (21)
HCV Protease (21)
PDGFR (20)
Estrogen Receptor/ERR (20)
Progesterone Receptor (20)
EGFR (17)
Proton pump (17)
PPAR (17)
Reactive Oxygen Species (17)
Influenza Virus (16)
Androgen Receptor (16)
Prostaglandin Receptor (15)
HBV (15)
ATPase (15)
JAK (15)
FLT (15)
Carbonic Anhydrase (14)
DNA Alkylator/Crosslinker (14)
FGFR (13)
Thrombin (13)
MAO (13)
Proteasome (12)
Src (12)
AChE (12)
Adenosine Receptor (12)
NF-κB (12)
ROS (11)
Raf (11)
Bcr-Abl (11)
Virus Protease (11)
c-Met/HGFR (11)
Tyrosine Kinases (11)
Monoamine Oxidase (10)
DHFR (10)
Transferase (10)
ALK (10)
MRP (10)
SGLT (9)
iGluR (9)
Antifolate (9)
HMG-CoA Reductase (9)
HDAC (9)
NO Synthase (9)
PI3K (9)
Drug Metabolite (9)
c-RET (9)
CDK (8)
GluR (8)
Phospholipase (8)
Retinoid Receptor (8)
P-gp (8)
mTOR (8)
MMP (8)
Opioid Receptor (8)
Thyroid hormone receptor(THR) (8)
Phosphatase (8)
ABC (8)
PARP (8)
TRP/TRPV Channel (8)
DNA gyrase (7)
HIF/HIF Prolyl-Hydroxylase (7)
DNA Methyltransferase (7)
MEK (7)
P2Y Receptor (7)
Factor Xa (7)
CaMK (7)
PKC (7)
DPP-4 (7)
DNA Alkylation (6)
S1P Receptor (6)
NMDAR (6)
LPL Receptor (6)
STAT (6)
Trk receptor (6)
CAT (6)
Endothelin Receptor (6)
TAM Receptor (6)
Histone Methyltransferase (5)
Hedgehog/Smoothened (5)
IL Receptor (5)
TNF (5)
Neurokinin receptor (5)
Guanylate cyclase (5)
TLR (5)
Ras (5)
GPR (5)
ERK (5)
Nrf2 (5)
ROS Kinase (5)
CFTR (5)
Lipoxygenase (5)
Monoamine Transporter (5)
Glutathione Peroxidase (4)
NADPH (4)
Antiviral (4)
FXR (4)
AMPK (4)
Integrin (4)
HER (4)
AhR (4)
Annexin A (4)
BTK (4)
Amino Acids and Derivatives (4)
HIF (4)
Hydroxylase (3)
GNRH Receptor (3)
Reductase (3)
Interleukin (3)
Akt (3)
Gamma-secretase (3)
NOS (3)
MT Receptor (3)
GST (3)
GPCR19 (3)
Decarboxylase (3)
Ligand for E3 Ligase (3)
Histone Demethylase (3)
Neprilysin (3)
DNA (3)
ROCK (3)
BCL (3)
Aryl Hydrocarbon Receptor (3)
Isocitrate Dehydrogenase (IDH) (3)
Fatty Acid Synthase (3)
Smo (3)
Cysteine Protease (3)
IGF-1R (3)
Molecular Glues (3)
PAK (3)
LDL (3)
Mitochondrial Metabolism (3)
Arginase (2)
c-Fms (2)
Cell wall (2)
Rho (2)
Beta Amyloid (2)
CCR (2)
Antioxidant (2)
Leukotriene Receptor (2)
IRE1 (2)
Integrase (2)
Adenosine deaminase (2)
Ligands for Target Protein for PROTAC (2)
UGT (2)
CETP (2)
CGRP Receptor (2)
CRM1 (2)
Gap Junction Protein (2)
Caspase (2)
Syk (2)
Sigma receptor (2)
Protease-activated Receptor (2)
Na-K-Cl cotransporter (2)
P2X Receptor (2)
Chloride channel (2)
PKM (2)
RSV (2)
Melanocortin Receptor (2)
Beta-Secretase (2)
Melatonin Receptor (2)
GluCls (2)
Glutathione reductase (2)
Lipid (2)
GSK-3 (2)
Xanthine Oxidase (2)
Thrombopoietin Receptor (2)
PGE Synthase (2)
Ephrin Receptor (2)
Free radical scavengers (2)
CaSR (2)
NOD-like Receptor (NLR) (1)
ROR (1)
Glucagon Receptor (1)
Epigenetic Reader Domain (1)
ATP Citrate Lyase (1)
Phosphorylase (1)
Platelet aggregation (1)
DNA-PK (1)
VDA (1)
DUB (1)
Anti-infection (1)
Telomerase (1)
NADPH-oxidase (1)
Adiponectin receptor (1)
GRK (1)
Hydrogenase (1)
TGF-beta/Smad (1)
Wnt/beta-catenin (1)
NPC1L1 (1)
Tyrosinase (1)
Glucosidase (1)
MTH1 (1)
GlyT (1)
Hexokinase (1)
Pyroptosis (1)
IAP (1)
OX Receptor (1)
CXCR (1)
Vasopressin Receptor (1)
IκB/IKK (1)
Angiotensin-converting Enzyme (ACE) (1)
Chk (1)
FAAH (1)
RAR/RXR  (1)
Somatostatin (1)
Serine Protease (1)
STING (1)
IFNAR (1)
JNK (1)
CRISPR/Cas9 (1)
CSF-1R (1)
Complement System (1)
HSP (1)
Oxytocin Receptor (1)
ACK (1)
YAP (1)
Aquaporin (1)
gp120/CD4 (1)
TOPK (1)
PROTAC Linker (1)
OAT (1)
PLK (1)
Myosin (1)
MAPK (1)
p38 MAPK (1)
PKA (1)

化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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