Lonazolac

Name: Lonazolac
Brand: TargetMol
SKU: T50025
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.40%

货号 T50025Cas号 53808-88-1

别名 氯那唑酸

Lonazolac 是一种具有抗炎特性的非甾体抗风湿剂。

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Lonazolac

一键复制产品信息

很棒

纯度: 99.40%

货号 T50025 别名 氯那唑酸Cas号 53808-88-1

Lonazolac 是一种具有抗炎特性的非甾体抗风湿剂。

规格	价格	库存
1 mg	¥ 198	现货
5 mg	¥ 431	现货
10 mg	¥ 646	现货
25 mg	¥ 1,090	现货
50 mg	¥ 1,650	现货
100 mg	¥ 2,480	现货
200 mg	¥ 3,720	现货
1 mL x 10 mM (in DMSO)	¥ 396	现货

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纯度: 99.40%

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COA LCMS 产品操作手册

产品介绍

Lonazolac AI Summary

Lonazolac exhibits bioactivity as an inhibitor across several biochemical targets. It is a potent inhibitor of Human Jumonji Domain Containing 2E (JMJD2E) with a potency of 28183.8 nM, Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) at 44668.4 nM, and Polymerase Iota at 56234.1 nM. It induces DNA re-replication in both MCF 10a normal breast cells (18356.4 nM) and SW480 colon adenocarcinoma cells (7307.8 nM). Additionally, it inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 33498.3 nM in the absence of CPT and 29855.4 nM in the presence of CPT, and it shows inhibitory action in the PTHR assay at 39810.7 nM. Furthermore, Lonazolac blocks Ebola Virus entry with AC50 values ranging from 3.981 μM to 3981.1 nM. It demonstrates moderate hepatotoxicity, with acute liver toxicity noted during clinical trials, but it does not cause cholestatic liver toxicity. It also has a high plasma protein binding potential (99.82%), influencing its distribution and bioavailability. Lonazolac shows antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 cells, with an IC50 value greater than 19952.62 nM after 48 hours. Binding assays reveal that Lonazolac generally exhibits weak or negligible bioactivity (AC50 values >30000.0 nM) in most receptor and transporter interactions, with notable moderate binding affinity to human DRD2 (AC50 of 830.0 nM). Thus, despite its various inhibitory effects, it does not display significant bioactivity in some tested interactions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Lonazolac is a nonsteroidal anti-inflammatory drug[1].
别名	氯那唑酸

化学信息

分子量	312.75
分子式	C₁₇H₁₃ClN₂O₂
CAS No.	53808-88-1
Smiles	C(C(O)=O)C=1C(=NN(C1)C2=CC=CC=C2)C3=CC=C(Cl)C=C3
密度	1.3g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (159.87 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1974 mL	15.9872 mL	31.9744 mL	159.8721 mL
5 mM	0.6395 mL	3.1974 mL	6.3949 mL	31.9744 mL
10 mM	0.3197 mL	1.5987 mL	3.1974 mL	15.9872 mL
20 mM	0.1599 mL	0.7994 mL	1.5987 mL	7.9936 mL
50 mM	0.0639 mL	0.3197 mL	0.6395 mL	3.1974 mL
100 mM	0.0320 mL	0.1599 mL	0.3197 mL	1.5987 mL