购物车

您的购物车当前为空

C-021

Name: C-021
Brand: TargetMol
SKU: T21870
Price: 387 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-

货号 T21870Cas号 864289-85-0 一键复制产品信息纯度: 99.90%

很棒

C 021 dihydrochloride 是一种 CC 趋化因子受体 4 (CCR4) 拮抗剂，抑制人和小鼠的功能趋化性，IC50分别为 140 和 39 nM。C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) 可有效阻止人 CCL22 衍生的 [35S]GTPγS 与受体结合，IC50为 18 nM。

C-021

一键复制产品信息

很棒

纯度: 99.90%

货号 T21870Cas号 864289-85-0

别名 4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-

规格	价格	库存
1 mg	¥ 387	现货
2 mg	¥ 559	现货
5 mg	¥ 932	现货
10 mg	¥ 1,370	现货
25 mg	¥ 2,320	现货
50 mg	¥ 3,460	现货
100 mg	¥ 4,930	现货
1 mL x 10 mM (in DMSO)	¥ 679	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。如您有任何问题，欢迎咨询，我们将竭诚为您服务。

凭借在化合物合成方面的丰富经验，我们可以根据您的研究需求为该产品提供快速定制合成服务。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.90%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

C-021 AI Summary

C-021 has been characterized for various pharmacological activities and metabolic properties. It exhibits potent antagonist activity at both human and mouse CCR4 receptors, demonstrating inhibition of CCL22-induced chemotaxis and [35S]GTPgammaS binding in mouse B300-19 cells, with IC50 values of 18.0 nM and 39.0 nM, respectively. For human CCR4 receptors, IC50 values are 140.0 nM for CCL22-induced chemotaxis. Metabolic studies indicate a high intrinsic clearance in human liver microsomes, with a CL value of 289.62 mL.min^-1.kg^-1, suggesting a rapid metabolism and potentially short half-life in vivo. In addition to its CCR4 receptor antagonist activity, C-021 shows anti-inflammatory properties by inhibiting oxazolone-induced contact hypersensitivity in a BALB/c mouse model, reducing ear swelling by 2.0% at an oral dose of 30 mg/kg twice daily. The compound also exhibits antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 cells with a 6.45% inhibition rate at 10 µM concentration over 48 hours, and showing minimal inhibition of cytotoxicity in VERO-6 cells under similar conditions. Moreover, it inhibits the SARS-CoV-2 3CL-Pro protease by -16.53% at a concentration of 20 µM. Furthermore, C-021 displays inhibitory activity against human HDAC6 enzyme in enzymatic assays, though with relatively low inhibition percentages of 0.07% and 0.13% using different peptide substrates. This diverse range of activities highlights its potential utility in therapeutic applications across various fields, including immunology, virology, and inflammation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 nM, respectively. It effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor (IC50: 18 nM).
靶点活性	CCR4:140 nM (human), CCR4:39 nM(mice)
别名	4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-

化学信息

分子量	467.65
分子式	C₂₇H₄₁N₅O₂
CAS No.	864289-85-0
Smiles	N(C=1C2=C(N=C(N1)N3CCC(CC3)N4CCCCC4)C=C(OC)C(OC)=C2)C5CCCCCC5
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 9 mg/mL (19.25 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 0.5 mg/mL (1.07 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1384 mL	10.6918 mL	21.3835 mL	106.9176 mL
5 mM	0.4277 mL	2.1384 mL	4.2767 mL	21.3835 mL
10 mM	0.2138 mL	1.0692 mL	2.1384 mL	10.6918 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。